The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene.

The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Research Abstract Details 

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The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Abstract Text:

M Takahashi,H Haro,Y Wakabayashi,T Kawa-uchi,H Komori,K Shinomiya,

It has been suggested that matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of intervertebral discs (IVDs). A human MMP-3 promoter 5A/6A polymorphism was reported to be involved in the regulation of MMP-3 gene expression. We suggest that IVD degeneration is associated with 5A/6A polymorphism. We studied 54 young and 49 elderly Japanese subjects. Degeneration of the lumbar discs was graded using MRI in the younger group and by radiography in the elderly. 5A/6A polymorphism was determined by polymerase-chain reaction-based assays. We found that the 5A5A and 5A6A genotype in the elderly was associated with a significantly larger number of degenerative IVDs than the 6A6A (p < 0.05), but there was no significant difference in the young. In the elderly, the IVD degenerative scores were also distributed more highly in the 5A5A and 5A6A genotypes (p = 0.0029). Our findings indicate that the 5A allele is a possible risk factor for the acceleration of degenerative changes in the lumbar disc in the elderly.

The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Publishing Authors By Initials

M Takahashi,H Haro,Y Wakabayashi,T Kawa-uchi,H Komori,K Shinomiya,

For similar musculoskeletal diseases: bone diseases: spinal diseases research abstracts see: musculoskeletal diseases: bone diseases: spinal diseases research

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The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 83

Page Numbers: 491-5

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ISSN: 0301-620X

DAY: 14

MONTH: May

YEAR: 2001

The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Information

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LANGUAGE: eng

NlmUniqueID: 375355

The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Keywords Mesh Terms:

KEYWORDS: Spinal Diseases

MESH TERMS: genetics

Chemical & Substance for Abstract: The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene. Information

Substance Name: Matrix Metalloproteinase 3

Registry Number: EC 3.4.24.17

Grant and Affiliation Information for The association of degeneration of the intervertebral disc with 5a/6a polymorphism in the promoter of the human matrix metalloproteinase-3 gene.

AFFILIATION: Department of Frontier Surgical Therapeutics, Tokyo Medical and Dental University, Japan.

Country: England

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MEDLINETA: J Bone Joint Surg Br

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