The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study.

The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Research Abstract Details 

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The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Abstract Text:

Laura J Rasmussen-Torvik,Mary Cushman,Michael Y Tsai,Yan Zhang,Susan R Heckbert,Wayne D Rosamond,Aaron R Folsom,Laura J Rasmussen-Torvik,Mary Cushman,Michael Y Tsai,Yan Zhang,Susan R Heckbert,Wayne D Rosamond,Aaron R Folsom,

INTRODUCTION: The alpha-fibrinogen Thr312Ala variant has been shown to influence clot structure through increased factor XIII cross-linking and formation of thicker fibrin fibers. However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study. MATERIALS AND METHODS: 506 cases and 1014 controls frequency matched on age, sex, race, and study were drawn from two prospective studies and included in the analysis. Logistic regression was used to examine the association between Thr312Ala and VTE. RESULTS: In a logistic regression model minimally adjusted for the matching variables, the Thr312Ala TA and AA genotypes were associated with a significantly higher risk of VTE than the TT genotype (TA OR and 95% confidence interval 1.27 [1.01-1.60], AA OR 1.49 [1.00-2.22]). Associations were similar in analyses of PE and DVT considered separately and across racial and study subgroups. The association between alpha-fibrinogen Thr312Ala and VTE was modified by both BMI and the FXIII Val34Leu variant; the combination of elevated BMI or FXIII Val34Leu with alpha-fibrinogen Thr312Ala conveyed lower odds of VTE than would be expected by an additive or multiplicative model of individual risk factors. CONCLUSIONS: These results suggest that alpha-fibrinogen Thr312Ala is involved in the pathogenesis of VTE and that its action may be modified by other VTE risk factors.

The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Publishing Authors By Initials

LJ Rasmussen-Torvik,M Cushman,MY Tsai,Y Zhang,SR Heckbert,WD Rosamond,AR Folsom,LJ Rasmussen-Torvik,M Cushman,MY Tsai,Y Zhang,SR Heckbert,WD Rosamond,AR Folsom,

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The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Thrombosis research

VOLUME: 121

Page Numbers: 1-7

Journal Abbreviation: Thromb. Res.

ISSN: 0049-3848

DAY: 11

MONTH: 04

YEAR: 2007

The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study. Information

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LANGUAGE: eng

NlmUniqueID: 326377

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AFFILIATION: Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S. Second St. Suite 300, Minneapolis, MN, 55454, United States.

Country: United States

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MEDLINETA: Thromb Res

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