The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.

The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Research Abstract Details 

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The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Abstract Text:

Jiping Chen,Stephen Lam,Aprile Pilon,Annette McWilliams,James Melby,Eva Szabo,

CC10, the secretory product of bronchiolar Clara cells, is infrequently expressed in non-small cell lung cancer (NSCLC), and its overexpression in NSCLC cell lines results in a less malignant phenotype. CC10 levels in bronchoalveolar lavage fluid (BAL) and serum are significantly lower in current smokers than healthy nonsmokers, but the effect of long-term smoking cessation on CC10 is unknown. We measured CC10 in baseline BAL and plasma collected from current (n = 81) and former (n = 23) smokers participating in a chemoprevention trial. Former smokers had significantly higher plasma CC10 levels compared with current smokers [mean, 62.1 ng/mL (95% CI, 43.0-81.2); range, 23.0-175.0 ng/mL for former smokers; and mean, 37.1 ng/mL (95% CI, 29.8-44.4); range, 5.0-171.0 ng/mL for current smokers; P < 0.001]. BAL CC10 levels also trended in the same direction. A significant positive correlation was found between CC10 plasma and BAL levels. After adjustment for age, sex, and pack-years of cigarette consumption, former smokers had 1.70 (95% CI, 1.23-2.36) times higher plasma CC10 levels than current smokers (P < 0.01), whereas former smokers also had nonsignificantly higher baseline BAL CC10 levels compared with current smokers [adjusted mean ratio (95% CI), 1.60 (0.92-2.80), P = 0.094 and 1.35 (0.86-2.10), P = 0.193 for the absolute and normalized BAL CC10, respectively]. These results show that sustained smoking cessation is associated with higher plasma CC10 levels, suggesting that at least some of the damage associated with tobacco smoke may be repaired by long-term smoking cessation.

The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Publishing Authors By Initials

J Chen,S Lam,A Pilon,A McWilliams,J Melby,E Szabo,

For similar uteroglobin research abstracts see: uteroglobin research

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The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 577-83

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 3

MONTH: Mar

YEAR: 2007

The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9200608

The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Keywords Mesh Terms:

KEYWORDS: Uteroglobin

MESH TERMS: metabolism

Chemical & Substance for Abstract: The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial. Information

Substance Name: Uteroglobin

Registry Number: 9060-09-7

Grant and Affiliation Information for The association between the anti-inflammatory protein CC10 and smoking status among participants in a chemoprevention trial.

AFFILIATION: Cancer Prevention Fellowship Program, National Cancer Institute, 6130 Executive Boulevard, Room 2132, Bethesda, MD 20892, USA.

Country: United States

AGENCY: United States NCI

GRANT: N01-CN-85188

ACRONYM: CN

MEDLINETA: Cancer Epidemiol Biomarkers Pr

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