The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men.

The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Research Abstract Details 

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The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Abstract Text:

Robin P Peeters,Wendy M van der Deure,Annewieke W van den Beld,Hans van Toor,Steven W J Lamberts,Joop A M J L Janssen, Uitterlinden,Theo J Visser,

BACKGROUND: Variations in thyroid function within the normal range are associated with differences in metabolism and body composition. For instance, TSH is positively associated with body mass index (BMI). This could be due to alterations in thyroid hormone activity, or to direct effects of TSH, as the TSH receptor (TSHR) is also expressed in adipose tissue. The TSHR-Asp727Glu polymorphism is associated with lower serum TSH levels in vivo. In this study, we analysed whether serum thyroid parameters and the TSHR-Asp727Glu polymorphism were associated with glucose metabolism and insulin resistance. In addition, we analysed the Thr92Ala polymorphism in the type 2 deiodinase (D2), which was recently associated with insulin resistance. METHODS: Genotypes were determined in a population of 349 elderly men (age 77.7 +/- 3.5 years), for whom serum thyroid parameters and data on insulin resistance, such as fasting blood glucose, serum insulin and homeostasis model assessment (HOMA) values, were available. RESULTS: In nondiabetic, euthyroid subjects, TSH was positively associated with leptin levels, whereas FT4 and rT3 were significantly negatively correlated with insulin and HOMA. Carriers of the TSHR-Glu727 allele had a significantly higher glucose (P = 0.01), insulin (P = 0.001), glycated haemoglobin (HbA1c) (P = 0.002), HOMA (P = 0.001) and leptin (P = 0.008). The D2-Ala(92) allele showed a trend towards higher levels of insulin (P = 0.07) and a higher HOMA (P = 0.09). CONCLUSION: In this population of nondiabetic elderly men, serum thyroid parameters and the TSHR-Asp727Glu polymorphism were associated with relative insulin resistance. Our study suggests that genetic variation in TSHR plays a role in insulin resistance and thereby influences glucose metabolism.

The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Publishing Authors By Initials

RP Peeters,WM van der Deure,AW van den Beld,H van Toor,SW Lamberts,JA Janssen,AG Uitterlinden,TJ Visser,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine, reverse research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: thyroid hormones: thyronines: triiodothyronine, reverse research

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The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical endocrinology

VOLUME: 66

Page Numbers: 808-15

Journal Abbreviation: Clin. Endocrinol. (Oxf)

ISSN: 0300-0664

DAY: 4

MONTH: 04

YEAR: 2007

The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Information

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LANGUAGE: eng

NlmUniqueID: 346653

The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Keywords Mesh Terms:

KEYWORDS: Triiodothyronine, Reverse

MESH TERMS: blood

Chemical & Substance for Abstract: The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men. Information

Substance Name: Thyrotropin

Registry Number: 9002-71-5

Grant and Affiliation Information for The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men.

AFFILIATION: Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands. r.peeters@erasmusmc.nl

Country: England

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MEDLINETA: Clin Endocrinol (Oxf)

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