The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems.

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Research Abstract Details 

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The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Abstract Text:

Brian J McMillan,Christopher A Bradfield,

For more than 30 years, the aryl hydrocarbon receptor [Ah receptor (AHR)] has been extensively scrutinized as the cellular receptor for numerous environmental contaminants, including polychlorinated dioxins, dibenzofurans, and biphenyls. Recent evidence argues that this description is incomplete and perhaps myopic. Ah receptor orthologs have been demonstrated to mediate diverse endogenous functions in our close vertebrate relatives as well as our distant invertebrate ancestors. Moreover, these endogenous functions suggest that xenobiotic toxicity may be best understood in the context of intrinsic AHR physiology. In this literature review, we survey the emerging picture of endogenous AHR biology from work in the vertebrate and invertebrate model systems Mus musculus, Caenorhabditis elegans, and Drosophila melanogaster.

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Publishing Authors By Initials

BJ McMillan,CA Bradfield,

For similar pharmaceutical preparations: xenobiotics research abstracts see: pharmaceutical preparations: xenobiotics research

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The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular pharmacology

VOLUME: 72

Page Numbers: 487-98

Journal Abbreviation: Mol. Pharmacol.

ISSN: 0026-895X

DAY: 29

MONTH: 05

YEAR: 2007

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Information

Number of References: 175

LANGUAGE: eng

NlmUniqueID: 35623

The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Keywords Mesh Terms:

KEYWORDS: Xenobiotics

MESH TERMS: metabolism

Chemical & Substance for Abstract: The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Information

Substance Name: Xenobiotics

Registry Number: 0

Grant and Affiliation Information for The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems.

AFFILIATION: McArdle Laboratory for Cancer Research, University of Wisconsin Shool of Medicine and Public Health, Madison, Wisconsin, USA.

Country: United States

AGENCY: United States NCI

GRANT: T32-CA009135

ACRONYM: CA

MEDLINETA: Mol Pharmacol

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