The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection.

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Research Abstract Details 

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The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Abstract Text:

Christopher C Kemball,Christopher D Pack,Heath M Guay,Zhu-Nan Li,David A Steinhauer,Eva Szomolanyi-Tsuda,Aron E Lukacher,

Although many studies have investigated the requirement for CD4(+) T cell help for CD8(+) T cell responses to acute viral infections that are fully resolved, less is known about the role of CD4(+) T cells in maintaining ongoing CD8(+) T cell responses to persistently infecting viruses. Using mouse polyoma virus (PyV), we asked whether CD4(+) T cell help is required to maintain antiviral CD8(+) T cell and humoral responses during acute and persistent phases of infection. Though fully intact during acute infection, the PyV-specific CD8(+) T cell response declined numerically during persistent infection in MHC class II-deficient mice, leaving a small antiviral CD8(+) T cell population that was maintained long term. These unhelped PyV-specific CD8(+) T cells were functionally unimpaired; they retained the potential for robust expansion and cytokine production in response to Ag rechallenge. In addition, although a strong antiviral IgG response was initially elicited by MHC class II-deficient mice, these Ab titers fell, and long-lived PyV-specific Ab-secreting cells were not detected in the bone marrow. Finally, using a minimally myeloablative mixed bone marrow chimerism approach, we demonstrate that recruitment and/or maintenance of new virus-specific CD8(+) T cells during persistent infection is impaired in the absence of MHC class II-restricted T cells. In summary, these studies show that CD4(+) T cells differentially affect CD8(+) T cell responses over the course of a persistent virus infection.

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Publishing Authors By Initials

CC Kemball,CD Pack,HM Guay,ZN Li,DA Steinhauer,E Szomolanyi-Tsuda,AE Lukacher,

For similar virus diseases: dna virus infections: polyomavirus infections research abstracts see: virus diseases: dna virus infections: polyomavirus infections research

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The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 1113-21

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Jul

YEAR: 2007

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Keywords Mesh Terms:

KEYWORDS: Polyomavirus Infections

MESH TERMS: immunology

Chemical & Substance for Abstract: The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection. Information

Substance Name: Histocompatibility Antigens Class II

Registry Number: 0

Grant and Affiliation Information for The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection.

AFFILIATION: Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32AI07272

ACRONYM: AI

MEDLINETA: J Immunol

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• The antiviral CD8+ T cell response is differentially dependent on CD4+ T cell help over the course of persistent infection.