The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations.

The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations. Research Abstract Details 

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The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations. Abstract Text:

Alma Rosa ,Alba Jady Delgadillo,Marcela Hurtado,Adriana Miriam , Medina,Kazuko Aoki,

The antispasmodic activity of extracts from the aerial parts of Buddleja scordioides and Buddleja perfoliata (family: Scrophulariaceae) was studied on isolated tissue preparations from rabbit and guinea pig intestine. The chloroformic extract from the plants exhibited a significant relaxation on the spontaneous contraction of isolated rabbit jejunum at concentrations ranging from 1 to 400 mug/ml, and also caused an inhibitory effect on both K(+) and Ca(2+) induced contractions in the same tissue. The extracts at moderate doses (50 mug/ml) reduced 5-hydroxytryptamine (5-HT), acetylcholine and histamine induced contractions on isolated guinea pig ileum. Therefore, B. scordioides and B. perfoliata possess similar relaxant mechanism of action, in view of the fact that both inhibit K(+) induce contraction and act through serotoninic, muscarinic and histaminic receptors. So, these data support the idea that the extracts may interfere either with calcium mobilization from intracellular stores, or with calcium interaction with regulatory proteins (e.g., calmodulin), or in other steps in the calcium signaling pathway. This leads us to suggest that the spasmolytic effect of both Buddleja species on smooth muscular contractility are due to the same or similar compounds occurring in these two species, which might be present in similar quantities.

The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations. Publishing Authors By Initials

AR ,AJ Delgadillo,M Hurtado,AM ,JR Medina,K Aoki,

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The Antispasmodic Activity of Buddleja scordioides and Buddleja perfoliata on Isolated Intestinal Preparations. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 29

Page Numbers: 1186-90

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 6

MONTH: Jun

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 9311984

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AFFILIATION: Departamento Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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