The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats.

The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Research Abstract Details 

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The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Abstract Text:

Zhaohui Xu,Xiaoyan Wang,Mingmei Zhou,Liping Ma,Yi Deng,Hanjie Zhang,Aihua Zhao,Yongyu Zhang,Wei Jia,Zhaohui Xu,Xiaoyan Wang,Mingmei Zhou,Liping Ma,Yi Deng,Hanjie Zhang,Aihua Zhao,Yongyu Zhang,Wei Jia,

The antidiabetic activity of the total lignan from the plant Fructus Arctii, used in China for the control of diabetes, was investigated in models of alloxan-induced diabetic mice and hyperglycemic-hyperlipidemic diabetic rats. The biochemical parameters studied were: blood glucose, glucose tolerance, serum insulin, serum triglycerides, total cholesterol and high density lipoprotein (HDL). Total lignan was given to mice and rats daily for 10 days at doses of 2.0, 1.0, 0.5 g/kg and 1.38, 0.69, 0.35 g/kg respectively. The alloxan-diabetic animals showed significant reductions in plasma glucose, triglycerides and total cholesterol after treatment with the total lignan from the plant Fructus Arctii and glibenclamide (used as standard) compared with the diabetic controls, while the glucose tolerance, serum insulin level and HDL-cholesterol were elevated without the risk of hypoglycemia. In conclusion, the total lignan from the plant Fructus Arctii has been proven to be a safer antidiabetic agent and might help to prevent diabetic complications. It can serve as a good adjuvant in the present armamentarium of antidiabetic drugs. Copyright (c) 2007 John Wiley & Sons, Ltd.

The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Publishing Authors By Initials

Z Xu,X Wang,M Zhou,L Ma,Y Deng,H Zhang,A Zhao,Y Zhang,W Jia,Z Xu,X Wang,M Zhou,L Ma,Y Deng,H Zhang,A Zhao,Y Zhang,W Jia,

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The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytotherapy research : PTR

VOLUME: 22

Page Numbers: 97-101

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ISSN: 0951-418X

DAY: 3

MONTH: Jan

YEAR: 2008

The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats. Information

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LANGUAGE: eng

NlmUniqueID: 8904486

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AFFILIATION: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China.

Country: England

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MEDLINETA: Phytother Res

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