[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine]

[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine] Research Abstract Details 

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[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine] Abstract Text:

M Yu,J Yang,X Cao,

OBJECTIVE: To investigate the anti-leukemia activity of IL-2 and IL-3 genes co-transfected leukemia vaccine. METHODS: The vaccine was prepared with FBL-3 erythroleukemia cells which were in vitro transfected with IL-2 and/or IL-3 genes by recombinant adenovirus and then inactivated by 60Co irradiation. The vaccine was injected peritoneally into FBL-3 leukemia mice, and the tumor growth, survival time of the mice, cytotoxicities of the peritoneal macrophages, splenic NK cells and CTL cells were observed. RESULTS: A fter treatment with the vaccine, the leukemic cell tumor in the mice showed significant growth inhibition and the survival time of the mice were prolonged when treated with IL-2 transfected vaccine, the cytotoxicities of splenic NK and CTL were increased significantly, while in the case of IL-3 transfected vaccine, the number and cytotoxicity of peritoneal macrophages were increased. The antileukemia effect was augmented when treated with IL-2 and IL-3 genes co-transfected vaccine. The antileukemia activity of the vaccine was also augmented by low dose cyclophosphamide administration. CONCLUSION: Leukemia vaccine gained more antitumor effect via induction of antitumor immunity.

[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine] Publishing Authors By Initials

M Yu,J Yang,X Cao,

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[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 630-3

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 31

MONTH: Dec

YEAR: 1997

[The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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Grant and Affiliation Information for [The anti-leukemia effects of IL-2 and IL-3 genes co-transfected leukemia vaccine]

AFFILIATION: Department of Hematology, Changhai Hospital, Second Military Medical University, Shanghai 200433.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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