The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation.

The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation. Research Abstract Details 

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The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation. Abstract Text:

Y Kagawa,T Hamamoto,H Endo,

ATP synthase (F(o)F(1)) consists of F(1) (ATP-driven motor) and F(o) (H(+)-driven motor). F(1) is a complex of alpha(3)beta(3)gammadeltaepsilon subunits, and gamma is the rotating cam in alpha(3)beta(3). Thermophilic F(1) (TF(1)) is exceptional in that it can be crystallized as a beta monomer and an alpha(3)beta(3) oligomer, and it is sufficiently stable to allow alphabeta refolding and reassembly of hybrid complexes containing 1, 2, and 3 modified alpha or beta. The nucleotide-dependent open-close conversion of conformation is an inherent property of an isolated beta and energy and signals are transferred through alpha/beta interfaces. The catalytic and noncatalytic interfaces of both mitochondrial F(1) (MF(1)) and TF(1) were analyzed by an atom search within the limits of 0.40 nm across the alphabeta interfaces. Seven (plus thermophilic loop in TF(1)) contact areas are located at both the catalytic and noncatalytic interfaces on the open beta form. The number of contact areas on closed beta increased to 11 and 9, respectively, in the catalytic and noncatalytic interfaces. The interfaces in the barrel domain are immobile. The torsional elastic strain applied through the mobile areas is concentrated in hinge residues and the P-loop in beta. The notion of elastic energy in F(o)F(1) has been revised. X-ray crystallography of F(1) is a static snap shot of one state and the elastic hypotheses are still inconsistent with the structure, dyamics, and kinetics of F(o)F(1). The domain motion and elastic energy in F(o)F(1) will be elucidated by time-resolved crystallography.

The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation. Publishing Authors By Initials

Y Kagawa,T Hamamoto,H Endo,

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The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of bioenergetics and biomembranes

VOLUME: 32

Page Numbers: 471-84

Journal Abbreviation: J. Bioenerg. Biomembr.

ISSN: 0145-479X

DAY: 15

MONTH: Oct

YEAR: 2000

The alpha/beta Interfaces of alpha1beta1, alpha3beta3, and F1: Domain Motions and Elastic Energy Stored during gamma Rotation. Information

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LANGUAGE: eng

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AFFILIATION: Department of Biochemistry, Jichi Medical School, Minamikawachi, Tochigi, 329-0498, Graduate School, Women's University of Nutrition, Sakado, Saitama 350-0288, Japan; ykagawa@jichi.ac.jp; kagawa@sak.eiyo.ac.jp

Country: United States

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