[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility]

[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility] Research Abstract Details 

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[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility] Abstract Text:

Xiao-ping Zhao,Hui-min Zheng,Hui-jun Xie,Su-ju Ding,Da-ming Ren,

OBJECTIVE: To explore the association of the microsatellite polymorphisms in the promoter region of alpha-synuclein gene with the late-onset sporadic Parkinson's disease (PD) susceptibility. METHODS: The microsatellite polymorphism of alpha-synuclein gene was analyzed with amplified fragment length polymorphism (Amp-FLP) and semiautomatic fluorescent labeled genotyping technique. Association analysis was performed in 135 unrelated late-onset sporadic PD patients and 170 age-matched healthy controls. RESULTS: The distribution of the alleles of the dinucleotide repeats variants of alpha-synuclein gene promoter region in PD cases was significantly different from that in the healthy controls. The most frequent allele in PD patients was allele 269 bp, but in controls it was the 271 bp allele. Alleles of

[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility] Publishing Authors By Initials

XP Zhao,HM Zheng,HJ Xie,SJ Ding,DM Ren,

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[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 21

Page Numbers: 339-41

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 9

MONTH: Aug

YEAR: 2004

[The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility] Information

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LANGUAGE: chi

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AFFILIATION: Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 PR China. xiaopingzhao1@263.net

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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