The acute effects of gabapentin in combination with alcohol in heavy drinkers.

The acute effects of gabapentin in combination with alcohol in heavy drinkers. Research Abstract Details 

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The acute effects of gabapentin in combination with alcohol in heavy drinkers. Abstract Text:

Adam Bisaga,Suzette M Evans,

BACKGROUND: Alcohol effects in humans involve gamma-amino butyric acid (GABA) neurotransmission. It has been proposed that GABAergic medications may be effective in the treatment of alcohol dependence. This study evaluated the acute effects of gabapentin, an anticonvulsant that increases extracellular GABA, on the subjective, physiological, and performance effects of alcohol in heavy (mean 34 drinks per week) alcohol drinkers. METHODS: Seventeen volunteers without alcohol dependence were tested using a double-blind design with three 3-day long inpatient phases, each separated by at least a 1-week wash-out period. Each phase, gabapentin (0, 1000, or 2000mg) was administered 4h before alcohol (0.75g/kg), which was given in four divided doses every 20min. RESULTS: Gabapentin impaired the ability to balance without producing changes in subjective, physiological or other performance measures. Pretreatment with gabapentin did not significantly alter subjective and performance effects of alcohol and did not alter alcohol craving. Gabapentin, dose-dependently enhanced alcohol-induced tachycardia. CONCLUSIONS: Acute gabapentin administration was well tolerated in combination with alcohol, but did not alter the effects of alcohol.

The acute effects of gabapentin in combination with alcohol in heavy drinkers. Publishing Authors By Initials

A Bisaga,SM Evans,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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MEDLINE DATE:

The acute effects of gabapentin in combination with alcohol in heavy drinkers. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Drug and alcohol dependence

VOLUME: 83

Page Numbers: 25-32

Journal Abbreviation:

ISSN: 0376-8716

DAY: 17

MONTH: 11

YEAR: 2005

The acute effects of gabapentin in combination with alcohol in heavy drinkers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513587

The acute effects of gabapentin in combination with alcohol in heavy drinkers. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: pharmacology

Chemical & Substance for Abstract: The acute effects of gabapentin in combination with alcohol in heavy drinkers. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for The acute effects of gabapentin in combination with alcohol in heavy drinkers.

AFFILIATION: Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Dr., Unit #120, New York, NY 10032, USA. amb107@columbia.edu

Country: Ireland

AGENCY: United States NIMH

GRANT: MH 61274

ACRONYM: MH

MEDLINETA: Drug Alcohol Depend

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