The A2b adenosine receptor protects against vascular injury.

The A2b adenosine receptor protects against vascular injury. Research Abstract Details 

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The A2b adenosine receptor protects against vascular injury. Abstract Text:

Dan Yang,Milka Koupenova,Donald J McCrann,Katherine J Kopeikina,Herbert M Kagan,Barbara M Schreiber,Katya Ravid,Dan Yang,Milka Koupenova,Donald J McCrann,Katherine J Kopeikina,Herbert M Kagan,Barbara M Schreiber,Katya Ravid,Dan Yang,Milka Koupenova,Donald J McCrann,Katherine J Kopeikina,Herbert M Kagan,Barbara M Schreiber,Katya Ravid,Dan Yang,Milka Koupenova,Donald J McCrann,Katherine J Kopeikina,Herbert M Kagan,Barbara M Schreiber,Katya Ravid,

The A2b adenosine receptor (A2bAR) is highly abundant in bone marrow macrophages and vascular smooth muscle cells (VSMC). To examine the functional significance of this receptor expression, we applied a femoral artery injury model to A2bAR knockout (KO) mice and showed that the A2bAR prevents vascular lesion formation in an injury model that resembles human restenosis after angioplasty. While considering related mechanisms, we noted higher levels of TNF-alpha, an up-regulator of CXCR4, and of VSMC proliferation in the injured KO mice. In accordance, CXCR4, which is known to attract progenitor cells during tissue regeneration, is up-regulated in lesions of the KO mice. In addition, aortic smooth muscle cells derived from A2bAR KO mice display greater proliferation in comparison with controls. Bone marrow transplantation experiments indicated that the majority of the signal for lesion formation in the null mice originates from bone marrow cells. Thus, this study highlights the significance of the A2bAR in regulating CXCR4 expression in vivo and in protecting against vascular lesion formation.

The A2b adenosine receptor protects against vascular injury. Publishing Authors By Initials

D Yang,M Koupenova,DJ McCrann,KJ Kopeikina,HM Kagan,BM Schreiber,K Ravid,D Yang,M Koupenova,DJ McCrann,KJ Kopeikina,HM Kagan,BM Schreiber,K Ravid,D Yang,M Koupenova,DJ McCrann,KJ Kopeikina,HM Kagan,BM Schreiber,K Ravid,D Yang,M Koupenova,DJ McCrann,KJ Kopeikina,HM Kagan,BM Schreiber,K Ravid,

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The A2b adenosine receptor protects against vascular injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 792-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 9

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for The A2b adenosine receptor protects against vascular injury.

AFFILIATION: Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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