The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study.

The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Research Abstract Details 

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The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Abstract Text:

Alfonso Tortorella,Palmiero Monteleone,Vassilis Martiadis,Francesco Perris,Mario Maj,Alfonso Tortorella,Palmiero Monteleone,Vassilis Martiadis,Francesco Perris,Mario Maj,Alfonso Tortorella,Palmiero Monteleone,Vassilis Martiadis,Francesco Perris,Mario Maj,

Feeding is subjected to circadian regulation; therefore, changes in the components of the endogenous oscillator regulating circadian rhythms may be involved in disordered rhythmicity of eating behavior as it occurs in anorexia nervosa (AN) and bulimia nervosa (BN). We investigated whether the 3111T/C polymorphism of the CLOCK gene, which is part of the endogenous oscillator system, was associated to AN and/or BN. A total of 241 women, including 90 healthy controls, 60 patients with AN and 91 patients with BN, participated into the study. The frequencies of 3111T/C genotypes and alleles did not significantly differ among the groups. In both the AN and BN group, subjects carrying one copy of the C allele had a lifetime body weight significantly lower than those carrying the T/T genotype. These findings, although preliminary, suggest that the 3111T/C polymorphism of the CLOCK gene does not play a major role in the genetic vulnerability to AN and BN, but it seems to predispose eating disorders (EDs) patients to a more severe lifetime body weight loss. (c) 2007 Wiley-Liss, Inc.

The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Publishing Authors By Initials

A Tortorella,P Monteleone,V Martiadis,F Perris,M Maj,A Tortorella,P Monteleone,V Martiadis,F Perris,M Maj,A Tortorella,P Monteleone,V Martiadis,F Perris,M Maj,

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The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 144

Page Numbers: 992-5

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 5

MONTH: Dec

YEAR: 2007

The 3111T/C polymorphism of the CLOCK gene confers a predisposition to a lifetime lower body weight in patients with anorexia nervosa and bulimia nervosa: A preliminary study. Information

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LANGUAGE: eng

NlmUniqueID: 101235742

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AFFILIATION: Department of Psychiatry, University of Naples SUN, Naples, Italy.

Country: United States

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MEDLINETA: Am J Med Genet B Neuropsychiat

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