TGIF, a gene associated with human brain defects, regulates neuronal development.

TGIF, a gene associated with human brain defects, regulates neuronal development. Research Abstract Details 

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TGIF, a gene associated with human brain defects, regulates neuronal development. Abstract Text:

Jessica L Knepper,Alison C James,Jeffrey E Ming,

5'-TG-3'-interacting factor (TGIF) is an atypical homeo-domain protein. In vitro studies have shown that TGIF can repress transcription mediated by either of two signaling pathways: TGF-beta and retinoic acid signaling. Mutations in TGIF have been detected in patients with holoprosencephaly (HPE), a severe brain malformation associated with mental retardation. Thus, TGIF must play an essential role in nervous system development. However, the precise function of TGIF during vertebrate neural development is unknown. To investigate the in vivo role of TGIF, we overexpressed TGIF in the developing chick neural tube. Overexpressed TGIF decreased expression of specific genes expressed in dorsally restricted domains of the neural tube, including Cath1, Ms x 2, Pa x 6, and Wnt1. In contrast, the expression of other transcription factors, including those necessary for ventral fate such as Nk x 2.2, was not affected. Furthermore, a missense mutation in TGIF identified in an HPE patient disrupted the activity of TGIF. In addition, the related protein TGIF2 did not demonstrate the same activity as TGIF. Our data suggest that TGIF plays an important role in regulating the expression of genes expressed in specific dorsal-ventral domains during neural development.

TGIF, a gene associated with human brain defects, regulates neuronal development. Publishing Authors By Initials

JL Knepper,AC James,JE Ming,

For similar nervous system: central nervous system: spinal cord research abstracts see: nervous system: central nervous system: spinal cord research

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TGIF, a gene associated with human brain defects, regulates neuronal development. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental dynamics : an official publication o

VOLUME: 235

Page Numbers: 1482-90

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 3

MONTH: Jun

YEAR: 2006

TGIF, a gene associated with human brain defects, regulates neuronal development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

TGIF, a gene associated with human brain defects, regulates neuronal development. Keywords Mesh Terms:

KEYWORDS: Spinal Cord

MESH TERMS: embryology

Chemical & Substance for Abstract: TGIF, a gene associated with human brain defects, regulates neuronal development. Information

Substance Name: TGIF1 protein, human

Registry Number: 0

Grant and Affiliation Information for TGIF, a gene associated with human brain defects, regulates neuronal development.

AFFILIATION: Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD29862

ACRONYM: HD

MEDLINETA: Dev Dyn

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