TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo.

TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Research Abstract Details 

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TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Abstract Text:

Benjamin Guglielmi,Julie Soutourina,Cyril Esnault,Michel Werner,

The transcription initiation and elongation steps of protein-coding genes usually rely on unrelated protein complexes. However, the TFIIS elongation factor is implicated in both processes. We found that, in the absence of the Med31 Mediator subunit, yeast cells required the TFIIS polymerase II (Pol II)-binding domain but not its RNA cleavage stimulatory activity that is associated with its elongation function. We also found that the TFIIS Pol II-interacting domain was needed for the full recruitment of Pol II to several promoters in the absence of Med31. This work demonstrated that, in addition to its thoroughly characterized role in transcription elongation, TFIIS is implicated through its Pol II-binding domain in the formation or stabilization of the transcription initiation complex in vivo.

TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Publishing Authors By Initials

B Guglielmi,J Soutourina,C Esnault,M Werner,

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TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 16062-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 27

MONTH: 09

YEAR: 2007

TFIIS elongation factor and Mediator act in conjunction during transcription initiation in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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AFFILIATION: Commissariat à l'Energie Atomique, Institut de Biologie et Technologies de Saclay, Bâtiment 144, Commissariat à l'Energie Atomique/Saclay, Gif-sur-Yvette Cedex F-91191, France.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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