[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia]

[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia] Research Abstract Details 

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[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia] Abstract Text:

Y Xue,Y Pan,Z Liu,Y Guo,X Xie,

OBJECTIVE: To report two cases of leukemia with t(8;21) and tetraploid clones. METHODS: R-banding technique was used. RESULTS: Cytogenetic studies of BM cells at diagnosis revealed that each of the two cases had three related abnormal clones besides a normal one: 46, XY, t(8;21) (2%), 46, idem, add((7)(q31)(6.8%) and 92, idem x 2 (80.6%) in case 1 and 46, XX, t(8;21) (13.4%), 47, idem, + 4 (46.3%) and 94, idem x 2 (39.1%) in case 2. They did not obtain complete remission on chemotherapy and survived 4 and 6 months, respectively. CONCLUSION: Tetraploid or near tetraploid clones are secondary events which are specifically associated with t(8;21) leukemia and the prognosis of patients with this kind of abnormal karyotype is poor.

[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia] Publishing Authors By Initials

Y Xue,Y Pan,Z Liu,Y Guo,X Xie,

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[Tetraploid clones characterized by double 8;21 translocations in two patients with acute myeloid leukemia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 240-2

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: May

YEAR: 1997

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou Medical College, Suzhou 215006.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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