Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.

Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Research Abstract Details 

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Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Abstract Text:

C-H Tsai,J-H Hong,K-F Hsieh,H-W Hsiao,W-L Chuang,C-C Lee,W H McBride,C-S Chiang,

The aim of this study was to investigate means of increasing the efficiency with which cancer cell death following local radiation therapy (RT) is translated into the generation of tumor immunity since, if this were to be achieved, it would be expected to enhance the rates of disease-free recurrence and survival. Our investigations centered around the use of interleukin-3 (IL-3), expressed intratumorally using an inducible adenoviral vector, to alter the immunogenicity of established murine TRAMP-C1 prostate cancer receiving a course of fractionated local RT (7 Gy per fraction per day for 5 days). Because high systemic levels of IL-3 can be associated with toxicity, a tetracycline-regulated gene delivery system was employed. The results show that while intratumoral IL-3 expression or RT alone caused a modest delay in TRAMP-C1 tumor growth, the combination was synergistic with 50% of mice being cured and developing a long-term, tumor-specific state of immunity. Immunological analyses performed on splenic lymphocytes demonstrated that, compared to RT or IL-3 alone, combined treatment significantly increased the number of tumor-specific IFN-gamma-secreting and cytotoxic T cells. The study demonstrates that tetracycline-regulated IL-3 gene expression within tumors can enhance the immune response to prostate cancer and this can augment the efficacy of a course of RT without additional side effects.

Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Publishing Authors By Initials

CH Tsai,JH Hong,KF Hsieh,HW Hsiao,WL Chuang,CC Lee,WH McBride,CS Chiang,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthacenes: tetracyclines: tetracycline research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthacenes: tetracyclines: tetracycline research

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Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer gene therapy

VOLUME: 13

Page Numbers: 1082-92

Journal Abbreviation: Cancer Gene Ther.

ISSN: 0929-1903

DAY: 14

MONTH: 07

YEAR: 2006

Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9432230

Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Keywords Mesh Terms:

KEYWORDS: Tetracycline

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Information

Substance Name: Tetracycline

Registry Number: 60-54-8

Grant and Affiliation Information for Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.

AFFILIATION: Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan.

Country: England

AGENCY: United States NCI

GRANT: R01 CA-101752

ACRONYM: CA

MEDLINETA: Cancer Gene Ther

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