Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons.

Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Research Abstract Details 

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Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Abstract Text:

Seth A Townsend,Gilad D Evrony,Frank X Gu,Martin P Schulz,Robert H Brown,Robert Langer,

The use of nanoparticles for targeted drug delivery is often facilitated by specific conjugation of functional targeting molecules to the nanoparticle surface. We compared different biotin-binding proteins (avidin, streptavidin, or neutravidin) as crosslinkers to conjugate proteins to biodegradable nanoparticles prepared from poly(lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-biotin polymers. Avidin gave the highest levels of overall protein conjugation, whereas neutravidin minimized protein non-specific binding to the polymer. The tetanus toxin C fragment (TTC), which is efficiently retrogradely transported in neurons and binds to neurons with high specificity and affinity, retained the ability to bind to neuroblastoma cells following amine group modifications. TTC was conjugated to nanoparticles using neutravidin, and the resulting nanoparticles were shown to selectively target neuroblastoma cells in vitro. TTC-conjugated nanoparticles have the potential to serve as drug delivery vehicles targeted to the central nervous system.

Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Publishing Authors By Initials

SA Townsend,GD Evrony,FX Gu,MP Schulz,RH Brown,R Langer,

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Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomaterials

VOLUME: 28

Page Numbers: 5176-84

Journal Abbreviation: Biomaterials

ISSN: 0142-9612

DAY: 14

MONTH: 09

YEAR: 2007

Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons. Information

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LANGUAGE: eng

NlmUniqueID: 8100316

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Grant and Affiliation Information for Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons.

AFFILIATION: Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Country: England

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MEDLINETA: Biomaterials

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