Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model.

Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Research Abstract Details 

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Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Abstract Text:

Astrid Gutierrez-Zepeda,Yuan Luo,

Alzheimer's disease (AD) is affecting more people every year due to the increase in elderly population. This disease is characterized by senior plaques, containing aggregated amyloid beta peptide (A beta), and neurofibrillary tangles in the AD brains. The A beta depositions are thought to increase in cellular oxidative stress, which subsequently produces neuronal cell death in the patient s brain, causing loss of memory and, in the latter stages, dementia. Diverse models have been established to test this, "Amyloid Toxicity Hypothesis of AD". Among these, the use of the nematode Caenorhabditis elegans has some advantages. This invertebrate has its entire genome known, as well as numerous gene homologues to those seen in humans. In relationship with the cell model, the nematode gives the benefit of an organismal view of the disease. The nematode's short life span proves useful, when compared with that of mice, allowing mechanistic studies of the disease and pharmacological treatments. Alongside with other laboratories, we have used this in vivo model to correlate the Abeta expression with its toxicity through the observance of the organism's behavior to provide a better understanding of the cellular processes underlining AD.

Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Publishing Authors By Initials

A Gutierrez-Zepeda,Y Luo,

For similar inorganic chemicals: free radicals: reactive oxygen species research abstracts see: inorganic chemicals: free radicals: reactive oxygen species research

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Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 9

Page Numbers: 3333-8

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 09

YEAR: 2004

Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Information

Number of References: 43

LANGUAGE: eng

NlmUniqueID: 9709506

Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Keywords Mesh Terms:

KEYWORDS: Reactive Oxygen Species

MESH TERMS: metabolism

Chemical & Substance for Abstract: Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model. Information

Substance Name: Reactive Oxygen Species

Registry Number: 0

Grant and Affiliation Information for Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model.

AFFILIATION: Laboratory for Cellular and Molecular Neuroscience Research, Department of Biological Science, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.

Country: United States

AGENCY: United States NCCAM

GRANT: AT00293-01A2

ACRONYM: AT

MEDLINETA: Front Biosci

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