Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates.

Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. Research Abstract Details 

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Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. Abstract Text:

Kimberly Page-Shafer,Brandee L Pappalardo,Leslie H Tobler,Bruce H Phelps,Brian R Edlin,Andrew R Moss,Teresa L Wright,David J Wright,Thomas R O'Brien,Sally Caglioti,Michael P Busch,Kimberly Page-Shafer,Brandee L Pappalardo,Leslie H Tobler,Bruce H Phelps,Brian R Edlin,Andrew R Moss,Teresa L Wright,David J Wright,Thomas R O'Brien,Sally Caglioti,Michael P Busch,

Surveillance for hepatitis C virus (HCV) is limited by the challenge of differentiating between acute and chronic infections. In this study, we evaluate a cross-sectional testing strategy that identifies individuals with acute HCV infection and we estimate HCV incidence. Anti-HCV-negative persons from four populations with various risks, i.e., blood donors, Veterans Administration (VA) patients, young injection drug users (IDU), and older IDU, were screened for HCV RNA by minipool or individual sample nucleic acid testing (NAT). The number of detected viremic seronegative infections was combined with the duration of the preseroconversion NAT-positive window period (derived from analysis of frequent serial samples from plasma donors followed from NAT detection to seroconversion) to estimate annual HCV incidence rates. Projected incidence rates were compared to observed incidence rates. Projected HCV incidence rates per 100 person-years were 0.0042 (95% confidence interval [95% CI], 0.0025 to 0.007) for blood donors, 0.86 (95% CI, 0.02 to 0.71) for VA patients, 39.8 (95% CI, 25.9 to 53.7) for young IDU, and 53.7 (95% CI, 23.4 to 108.8) for older IDU. Projected rates were most similar to observed incidence rates for young IDU (33.4; 95% CI, 28.0 to 39.9). This study demonstrates the value of applying a cross-sectional screening strategy to detect acute HCV infections and to estimate HCV incidence.

Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. Publishing Authors By Initials

K Page-Shafer,BL Pappalardo,LH Tobler,BH Phelps,BR Edlin,AR Moss,TL Wright,DJ Wright,TR O'Brien,S Caglioti,MP Busch,K Page-Shafer,BL Pappalardo,LH Tobler,BH Phelps,BR Edlin,AR Moss,TL Wright,DJ Wright,TR O'Brien,S Caglioti,MP Busch,

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Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical microbiology

VOLUME: 46

Page Numbers: 499-506

Journal Abbreviation: J. Clin. Microbiol.

ISSN: 0095-1137

DAY: 21

MONTH: 11

YEAR: 2007

Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Testing strategy to identify cases of acute hepatitis C virus (HCV) infection and to project HCV incidence rates.

AFFILIATION: Blood Systems Research Institute, 270 Masonic Ave., San Francisco, CA 94118. Mbusch@bloodsystems.org.

Country: United States

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MEDLINETA: J Clin Microbiol

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