Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.

Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Research Abstract Details 

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Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Abstract Text:

Rui Zhu,Yuan Ji,Lianchun Xiao,Angabin Matin,Rui Zhu,Yuan Ji,Lianchun Xiao,Angabin Matin,

Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here we report the identification of candidate disease genes from a CSS by using a combination of genetic and genomic approaches and by using knowledge about the germ cell tumor disease etiology. We used the CSS 129.MOLF-Chr19 chromosome substitution strain, in which males develop germ cell tumors of the testes at an extremely high rate. We were able to identify three protein-coding genes and one microRNA on chromosome 19 that have previously not been implicated to be testicular tumor susceptibility genes. Our findings suggest that changes in gene expression levels in the gonadal tissues of multiple genes from Chr 19 likely contribute to the high testicular germ cell tumor (TGCT) incidence of the 129.MOLF-Chr19 strain. Our data advance the use of CSS to identify disease susceptibility genes and demonstrate that the 129.MOLF-Chr19 strain serves as a useful model to elucidate the genetics and biology of germ cell transformation and tumor development.

Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Publishing Authors By Initials

R Zhu,Y Ji,L Xiao,A Matin,R Zhu,Y Ji,L Xiao,A Matin,

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Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mammalian genome : official journal of the Interna

VOLUME: 18

Page Numbers: 584-95

Journal Abbreviation: Mamm. Genome

ISSN: 0938-8990

DAY: 2

MONTH: 08

YEAR: 2007

Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Information

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LANGUAGE: eng

NlmUniqueID: 9100916

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Grant and Affiliation Information for Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.

AFFILIATION: Department of Cancer Genetics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1006, Houston, Texas 77030, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA093754

ACRONYM: CA

MEDLINETA: Mamm Genome

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