Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms.

Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Research Abstract Details 

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Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Abstract Text:

Ana M Catafau,Santiago Bullich, , Penengo,Albert Cot,Sergio Abanades, ,Javier , Ros,Ana M Catafau,Santiago Bullich, , Penengo,Albert Cot,Sergio Abanades, ,Javier , Ros,Ana M Catafau,Santiago Bullich, , Penengo,Albert Cot,Sergio Abanades, ,Javier , Ros,

Objective: (123)I-IBZM single photon emission computed tomography (SPECT) is a widely used method to measure D(2) receptor availability. However, test-retest variability and reliability have not been reported yet. This study aimed to further characterize (123)I-IBZM SPECT in healthy volunteers (HVs), by assessing (1) pseudoequilibrium interval after bolus injection; (2) normal specific uptake ratio (SUR) values using filtered-backprojection (FBP); and the iterative reconstruction algorithm ordered-subsets expectation maximization (OSEM); (3) test-retest variability and reliability (intraclass correlation coefficient); and (4) influence of OSEM on test-retest variability and reliability. Methods: Ten HVs (Group A) were scanned twice 48 h apart for test-retest variability and reliability measurements, and n = 4 of them were sequentially scanned over time. Eighteen HVs (Group B) were scanned once at pseudoequilibrium. For reconstruction FBP was used. Test-retest scans were reconstructed in addition using OSEM. SPECT-MRI coregistration was used for region of interest drawing. Results: Pseudoequilibrium was achieved at 90 min postinjection (p.i.) and maintained until the end of the SPECT session (n = 4), and mean SUR at this time point was 0.96 +/- 0.14 (Groups A + B, n = 28). Mean SUR at test was 0.96 +/- 0.19 and at retest 0.94 +/- 0.19 (Group A, n = 10). Using FBP, test-retest variability was (12.7 +/- 9.6)% and reliability was 0.74. Using OSEM with 18 equivalent iterations, test-retest variability and reliability were improved to (6.5 +/- 5.2)% and 0.84, respectively. Conclusions: (123)I-IBZM SPECT imaging using the bolus injection and a single scan at 90 min p.i. is a reproducible method showing acceptable test-retest variability and reliability. Test-retest variability and reliability can be substantially improved using OSEM with 12-36 equivalent iterations. Synapse 62:62-69, 2008. (c) 2007 Wiley-Liss, Inc.

Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Publishing Authors By Initials

AM Catafau,S Bullich,M ,MM Penengo,A Cot,S Abanades,M ,J ,D Ros,AM Catafau,S Bullich,M ,MM Penengo,A Cot,S Abanades,M ,J ,D Ros,AM Catafau,S Bullich,M ,MM Penengo,A Cot,S Abanades,M ,J ,D Ros,

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Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Synapse (New York, N.Y.)

VOLUME: 62

Page Numbers: 62-9

Journal Abbreviation: Synapse

ISSN: 0887-4476

DAY: 6

MONTH: Jan

YEAR: 2008

Test-retest variability and reliability of (123)I-IBZM SPECT measurement of striatal dopamine D(2) receptor availability in healthy volunteers and influence of iterative reconstruction algorithms. Information

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LANGUAGE: eng

NlmUniqueID: 8806914

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AFFILIATION: Experimental Medicine, Clinical Pharmacology Discovery Medicine, Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Barcelona, Spain.

Country: United States

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