Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics.

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Abstract Text:

R Sankar,

The approach to clinical decision-making pertaining to the use of antiepileptic drugs (AEDs) during pregnancy has relied on previous accumulated experience and, since the 1990s, on data from pregnancy registries. The limitations of this process are that no information regarding the chemical attributes of the AED under consideration, nor the role of a number of enzyme systems that are known to interact with foreign compounds to modify their potential for harm, are included. The role of the hepatic mixed function oxidase system may be especially important in conferring teratogenic risk. However, systems such as epoxide hydrolase, glutathione reductase, superoxide dismutase and other toxin-scavenging systems may be important modifiers that lower the risk. Knowledge is also accumulating on the interactions of AEDs with molecular targets such as histone deacetylase and peroxisome proliferator-activated receptors that may play important roles in teratogenesis. While our knowledge of these factors are incomplete, progress can be achieved by beginning to include these concepts in our discussion on the topic and by promoting research that may improve our ability to individualize the analysis of risk for a specific patient with regards to specific AEDs.

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Publishing Authors By Initials

R Sankar,

For similar female urogenital diseases and pregnancy complications: pregnancy complications research abstracts see: female urogenital diseases and pregnancy complications: pregnancy complications research

PUBMED ID PMID:

MEDLINE DATE:

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta neurologica Scandinavica

VOLUME: 116

Page Numbers: 65-71

Journal Abbreviation: Acta Neurol. Scand.

ISSN: 0001-6314

DAY: 3

MONTH: Jul

YEAR: 2007

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Information

Number of References: 36

LANGUAGE: eng

NlmUniqueID: 370336

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Keywords Mesh Terms:

KEYWORDS: Pregnancy Complications

MESH TERMS: metabolism

Chemical & Substance for Abstract: Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics. Information

Substance Name: Cytochrome P-450 Enzyme System

Registry Number: 9035-51-2

Grant and Affiliation Information for Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics.

AFFILIATION: David Geffen School of Medicine and Mattel Children's Hospital, UCLA, Los Angeles, CA 90095-1752, USA. rsankar@ucla.edu

Country: Denmark

AGENCY: United States NINDS

GRANT: NS046516

ACRONYM: NS

MEDLINETA: Acta Neurol Scand

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics Related Publications

• 9th Workshop on the Neurobiology of Epilepsy (WONOEP IX): the transition from the interictal to the ictal state (Teluk Nibong, Langkawi Island, Malaysia, July 4-7, 2007).
• Age-dependent effects of topiramate on the acquisition and the retention of rapid kindling.
• An educative genitourinary medicine clinic website: value to users and impact on service demand.
• Ascending peritonitis associated with Fallopian tube prolapse following hysterectomy.
• Being seen within 48 hours - what do patients think?
• Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.
• Ethnicity, ancestry, and race in molecular epidemiologic research.
• Goitrous autoimmune thyroiditis in a pediatric population: a longitudinal study.
• Inflammation exacerbates seizure-induced injury in the immature brain.
• Kindling epileptogenesis in immature rats leads to persistent depressive behavior.
• MEDLINE definitions of race and ethnicity and their application to genetic research.
• Predictors of uptake of obesity genetic testing among affected adults.
• STUDIES ON BIOGENIC AMINES AND PSYCHOACTIVE DRUG ACTIONS, WITH SPECIAL REFERENCE TO LYSERGIC ACID DIETHYL AMIDE.
• Shah-Waardenburg syndrome.
• Short humerus: an additional antenatal sonographic feature of OFDS type II.
• Spinal cord response to altered fractionation and re-irradiation: radiobiological considerations and role of bioeffect models.
• Status epilepticus: danse macabre in a ballet of subunits.
• Teratogenicity of antiepileptic drugs: role of drug metabolism and pharmacogenomics.