Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring.

Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Research Abstract Details 

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Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Abstract Text:

Zol B Kryger,Mark Sisco,Nakshatra K Roy,Leonard Lu,David Rosenberg,Thomas A Mustoe,

BACKGROUND: Despite numerous studies that have investigated the cellular and molecular mechanisms underlying scar formation, this process still remains poorly understood. The importance of transforming growth factor-beta (TGF-beta) in these processes has been well recognized, and this study sought to define the temporal expression of the key members in this pathway in a well-established, clinically relevant, rabbit ear model of hypertrophic scarring. STUDY DESIGN: Seven-millimeter (hypertrophic) and 5-mm (nonhypertrophic) punch wounds were made on the ears of 12 rabbits. Wounds were harvested at days 0, 7, 15, 28, and 40. RESULTS: There were no appreciable histologic differences between the 5- and 7-mm wounds at days 7 and 15. At day 28, however, the 7-mm scars were considerably more hypertrophic compared with the 5-mm control scars (p<0.001). The mRNA levels of TGF-beta1 and collagen Ialpha2 were notably higher in the hypertrophic 7-mm scars at day 28 than in the nonhypertrophic 5-mm scars (p<0.03). Although not pronounced, levels of TGF-beta2 were higher in the hypertrophic scars. There were no other statistically significant differences between the 7- and 5-mm scars. CONCLUSIONS: Elevated levels of TGF-beta1, and possibly TGF-beta2, are associated with hypertrophic scar formation.

Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Publishing Authors By Initials

ZB Kryger,M Sisco,NK Roy,L Lu,D Rosenberg,TA Mustoe,

For similar disorders of environmental origin: wounds and injuries: wounds, penetrating research abstracts see: disorders of environmental origin: wounds and injuries: wounds, penetrating research

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Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American College of Surgeons

VOLUME: 205

Page Numbers: 78-88

Journal Abbreviation: J. Am. Coll. Surg.

ISSN: 1072-7515

DAY: 3

MONTH: Jul

YEAR: 2007

Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9431305

Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Keywords Mesh Terms:

KEYWORDS: Wounds, Penetrating

MESH TERMS: metabolism

Chemical & Substance for Abstract: Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring. Information

Substance Name: Transforming Growth Factor beta

Registry Number: 0

Grant and Affiliation Information for Temporal expression of the transforming growth factor-Beta pathway in the rabbit ear model of wound healing and scarring.

AFFILIATION: Wound Healing Research Laboratory, Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM063825

ACRONYM: GM

MEDLINETA: J Am Coll Surg

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