Templated agarose scaffolds support linear axonal regeneration.

Templated agarose scaffolds support linear axonal regeneration. Research Abstract Details 

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Templated agarose scaffolds support linear axonal regeneration. Abstract Text:

Shula Stokols,Jeff Sakamoto,Chris Breckon,Todd Holt,James Weiss,Mark H Tuszynski,

While several strategies can stimulate axonal regeneration within a site of spinal cord injury, the growth of axons is generally disorganized and random. Biocompatible scaffolds that guide and maintain the native organization of axons regenerating through an injury site could be of importance in enhancing recovery of the nervous system after injury. Here we report a novel fabrication process for templated agarose nerve guidance scaffolds composed of uniaxial channels of precise diameter and wall thickness extending through their full length. When tested in an in vivo model of spinal cord injury, scaffolds exhibit excellent integration with host tissue and support linear axonal growth through their channels. Further, when loaded with bone marrow stromal cells genetically engineered to secrete brain-derived neurotrophic factor (BDNF), the number of linear penetrating axons is significantly enhanced. The templating process can be useful in fabricating nerve guidance scaffolds for both central and peripheral nerve injuries, or any materials application requiring a precise array of linearly oriented channels.

Templated agarose scaffolds support linear axonal regeneration. Publishing Authors By Initials

S Stokols,J Sakamoto,C Breckon,T Holt,J Weiss,MH Tuszynski,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Templated agarose scaffolds support linear axonal regeneration. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Tissue engineering

VOLUME: 12

Page Numbers: 2777-87

Journal Abbreviation: Tissue Eng.

ISSN: 1076-3279

DAY: 3

MONTH: Oct

YEAR: 2006

Templated agarose scaffolds support linear axonal regeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9505538

Templated agarose scaffolds support linear axonal regeneration. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Templated agarose scaffolds support linear axonal regeneration. Information

Substance Name: Sepharose

Registry Number: 9012-36-6

Grant and Affiliation Information for Templated agarose scaffolds support linear axonal regeneration.

AFFILIATION: Department of Bioengineering, University of California-San Diego, La Jolla, California 92093, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS09881

ACRONYM: NS

MEDLINETA: Tissue Eng

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