Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase.

Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Research Abstract Details 

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Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Abstract Text:

S K Vakkalanka,C S Brazel,N A Peppas,

Controlled release devices were designed which respond to changes in pH and temperature by reversibly swelling and deswelling to control release of streptokinase. Copolymer hydrogels composed of N-isopropylacrylamide (NIPAAm) and methacrylic acid (MAA) as well as terpolymer hydrogels containing NIPAAm, acrylic acid (AA), and 2-hydroxyethyl methacrylate (HEMA) were synthesized. Hydrogels containing NIPAAm display a change in swelling behavior across the lower critical solubility temperature of PNIPAAm, whereas hydrogels with MAA and AA swelled only at high pH values due to the ionization of carboxylic pendant groups. HEMA was chosen as a third component to add mechanical strength and integrity to the hydrogel. Pulsatile pH- and temperature-dependent swelling studies were performed to determine the extent and rate at which the hydrogels swell in response to changing conditions. Results showed that increasing the NIPAAm concentration in the copolymers or terpolymers resulted in a higher degree of temperature-sensitive swelling. Synthesis of a terpolymer in which segments rich in NIPAAm were distributed within P(AA-co-HEMA) chains led to hydrogels displaying increased temperature sensitivity. Streptokinase was incorporated into the hydrogels, and its release was observed under the combined effects of temperature and pH. The streptokinase release pattern followed the swelling state of the hydrogel, with drug release occurring at a significantly higher rate from the most swollen hydrogels.

Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Publishing Authors By Initials

SK Vakkalanka,CS Brazel,NA Peppas,

For similar water research abstracts see: water research

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Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 8

Page Numbers: 119-29

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1996

Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase. Information

Substance Name: Streptokinase

Registry Number: EC 3.4.-

Grant and Affiliation Information for Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase.

AFFILIATION: School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283, USA.

Country: NETHERLANDS

AGENCY: United States NIGMS

GRANT: GM43337

ACRONYM: GM

MEDLINETA: J Biomater Sci Polym Ed

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