Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi.

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Abstract Text:

Dilrukshi K Ekanayake,Michael J Cipriano,Robert Sabatini,Dilrukshi K Ekanayake,Michael J Cipriano,Robert Sabatini,

Base J or beta-d-glucosylhydroxymethyluracil is a modification of thymine residues within the genome of kinetoplastid parasites. In organisms known to contain the modified base, J is located mainly within the telomeric repeats. However, in Trypanosoma brucei, a small fraction of J is also located within the silent subtelomeric variant surface glycoprotein (VSG) gene expression sites, but not in the active expression site, suggesting a role for J in regulating telomeric genes involved in pathogenesis. With the identification of surface glycoprotein genes adjacent to telomeres in the South American Trypanosome, Trypanosoma cruzi, we became interested in the telomeric distribution of base J. Analysis of J and telomeric repeat sequences by J immunoblots and Southern blots following DNA digestion, reveals approximately 25% of J outside the telomeric repeat sequences. Moreover, the analysis of DNA sequences immunoprecipitated with J antiserum, localized J within subtelomeric regions rich in life-stage-specific surface glycoprotein genes involved in pathogenesis. Interestingly, the pattern of J within these regions is developmentally regulated. These studies provide a framework to characterize the role of base J in the regulation of telomeric gene expression/diversity in T. cruzi.

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Publishing Authors By Initials

DK Ekanayake,MJ Cipriano,R Sabatini,DK Ekanayake,MJ Cipriano,R Sabatini,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: 6367-77

Journal Abbreviation:

ISSN: 1362-4962

DAY: 18

MONTH: 09

YEAR: 2007

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 411011

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi.

AFFILIATION: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.

Country: England

AGENCY: United States PHS

GRANT: A1063523

ACRONYM:

MEDLINETA: Nucleic Acids Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi Related Publications

• Acetophenazine (Tindal) in the treatment of 80 chronically ill patients with anxiety and tension: double-blind study.
• Calcium signaling in dendrites and spines: practical and functional considerations.
• Cancer cell metabolism: warburg and beyond.
• CellProfiler: image analysis software for identifying and quantifying cell phenotypes.
• Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons.
• Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.
• Emerging role of cytokinin as a regulator of cellular differentiation.
• Extending the traditional resection limits of squamous cell carcinoma of the anterior skull base.
• Hydrophilic-lipophilic deviation (HLD) method for characterizing conventional and extended surfactants.
• Increased mTORC1 signaling UPRegulates stress.
• JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.
• Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
• Neuroscience: Neighbourly synapses.
• Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines.
• Not Available
• Recovery from amnesic confabulatory syndrome after right fornix lesion.
• Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels.
• Rhamnolipid biosurfactant mixtures for environmental remediation.
• Spectroscopic and computational studies of a Ru(II) terpyridine complex: the importance of weak intermolecular forces to photophysical properties.
• Telomeric co-localization of the modified base J and contingency genes in the protozoan parasite Trypanosoma cruzi.
• The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
• The use of chlordiazepoxide (Librium) in the alcoholic patient: a clinical study of forty cases.
• Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons.
• Use of a new benzodiazepine derivative (valium) in chronically ill and disturbed elderly patients.
• Voxel-based analysis of R2* maps in the healthy human brain.
• [Cutaneous lesions in man caused by virus of infectious pustular stomatitis of sheep.]
• [Dermatology and cosmetology. Dermatological legal petitions in current cosmetological practice]
• [Fisherman's dermatoses]
• [Saint's triad (esophageal hiatus hernia with cholelithiasis & diverticulosis of the colon.]
• [Therapeutic effects of chloroquine in children. In a case of malignant lupoerythemato visceritis and 2 cases of chronic rheumatism.]