Telomeres and telomerase in leukaemia and lymphoma.

Telomeres and telomerase in leukaemia and lymphoma. Research Abstract Details 

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Telomeres and telomerase in leukaemia and lymphoma. Abstract Text:

Glenda Mary Davison,Glenda Mary Davison,Glenda Mary Davison,

Telomeres are DNA structures which serve to stabilize chromosomes. In human cells telomeres progressively shorten with each cell division leading to eventual chromosome instability and cell death. Telomerase is a DNA polymerase which is required for the maintenance of telomeres. Therefore, telomeres and telomerase play a role in the regulation of the life span of the cell. Human cells express low levels of telomerase, however when telomere length reaches a critical level abnormal activation of telomerase can lead to immortalization and uncontrolled proliferation. This process has been associated with the development of many leukaemias and lymphomas. Understanding these processes in normal and malignant cells could lead to therapies which target the telomere/telomerase complex.

Telomeres and telomerase in leukaemia and lymphoma. Publishing Authors By Initials

GM Davison,GM Davison,GM Davison,

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Telomeres and telomerase in leukaemia and lymphoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transfusion and apheresis science : official journ

VOLUME: 37

Page Numbers: 43-7

Journal Abbreviation: Transfus. Apher. Sci.

ISSN: 1473-0502

DAY: 4

MONTH: 09

YEAR: 2007

Telomeres and telomerase in leukaemia and lymphoma. Information

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LANGUAGE: eng

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AFFILIATION: Cape Peninsula University of Technology, Department of Biomedical Technology, Faculty of Health and Wellness Sciences, P.O. Box 652, Cape Town 8000, South Africa.

Country: England

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MEDLINETA: Transfus Apher Sci

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