Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice.

Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Research Abstract Details 

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Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Abstract Text:

Troy C Lund,Robert W Grange,Dawn A Lowe,

The progression of Duchenne muscular dystrophy (DMD) is, in part, due to satellite cell senescence driven by high replicative pressure as these muscle stem cells repeatedly divide and fuse to damaged muscle fibers. We hypothesize that telomere shortening in satellite cells underlies their senescence. To test this hypothesis, we evaluated the diaphragm and a leg muscle from dystrophic mice of various ages for telomere dynamics. We found 30% telomere shortening in tibialis anterior muscles from 600-day-old mdx mice relative to age-matched wildtype mice. We also found a more severe shortening of telomere length in diaphragm muscles of old mdx mice. In those muscles, telomeres were shortened by approximately 15% and 40% in 100- and 600-day-old mdx mice, respectively. These findings indicate that satellite cells undergo telomere erosion, which may contribute to the inability of these cells to perpetually repair DMD muscle.

Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Publishing Authors By Initials

TC Lund,RW Grange,DA Lowe,

For similar musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research abstracts see: musculoskeletal system: skeleton: bone and bones: bones of lower extremity: leg bones: tibia research

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Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Muscle & nerve

VOLUME: 36

Page Numbers: 387-90

Journal Abbreviation: Muscle Nerve

ISSN: 0148-639X

DAY: 3

MONTH: Sep

YEAR: 2007

Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Information

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LANGUAGE: eng

NlmUniqueID: 7803146

Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice. Keywords Mesh Terms:

KEYWORDS: Tibia

MESH TERMS: metabolism

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Grant and Affiliation Information for Telomere shortening in diaphragm and tibialis anterior muscles of aged mdx mice.

AFFILIATION: Pediatric Hematology-Oncology and Blood and Marrow Transplant Program, University of Minnesota, School of Medicine, Minneapolis, Minnesota 55455, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR049881

ACRONYM: AR

MEDLINETA: Muscle Nerve

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