Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Telomere protection by mammalian Pot1 requires interaction with Tpp1. Research Abstract Details 

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Telomere protection by mammalian Pot1 requires interaction with Tpp1. Abstract Text:

Dirk Hockemeyer,Wilhelm Palm,Tobias Else,Jan-Peter Daniels,Kaori K Takai,Jeffrey Z-S Ye,Catherine E Keegan,Titia de Lange,Gary D Hammer,

The shelterin complex at mammalian telomeres contains the single-stranded DNA-binding protein Pot1, which regulates telomere length and protects chromosome ends. Pot1 binds Tpp1, the shelterin component that connects Pot1 to the duplex telomeric DNA-binding proteins Trf1 and Trf2. Control of telomere length requires that Pot1 binds Tpp1 as well as the single-stranded telomeric DNA, but it is not known whether the protective function of Pot1 depends on Tpp1. Alternatively, Pot1 might function similarly to the Pot1-like proteins of budding and fission yeast, which have no known Tpp1-like connection to the duplex telomeric DNA. Using mutant mouse cells with diminished Tpp1 levels, RNA interference directed to mouse Tpp1 and Pot1, and complementation of mouse Pot1 knockout cells with human and mouse Pot1 variants, we show here that Tpp1 is required for the protective function of mammalian Pot1 proteins.

Telomere protection by mammalian Pot1 requires interaction with Tpp1. Publishing Authors By Initials

D Hockemeyer,W Palm,T Else,JP Daniels,KK Takai,JZ Ye,CE Keegan,T de Lange,GD Hammer,

For similar proteins: dna-binding proteins: telomere-binding proteins research abstracts see: proteins: dna-binding proteins: telomere-binding proteins research

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Telomere protection by mammalian Pot1 requires interaction with Tpp1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 754-61

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9993

DAY: 15

MONTH: 07

YEAR: 2007

Telomere protection by mammalian Pot1 requires interaction with Tpp1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186374

Telomere protection by mammalian Pot1 requires interaction with Tpp1. Keywords Mesh Terms:

KEYWORDS: Telomere-Binding Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Telomere protection by mammalian Pot1 requires interaction with Tpp1. Information

Substance Name: shelterin, human

Registry Number: 0

Grant and Affiliation Information for Telomere protection by mammalian Pot1 requires interaction with Tpp1.

AFFILIATION: Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

Country: United States

AGENCY: United States NICHD

GRANT: K08-HD42487

ACRONYM: HD

MEDLINETA: Nat Struct Mol Biol

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