Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background.

Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. Research Abstract Details 

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Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. Abstract Text:

Ya-Hua Zhong,Zheng-Kai Liao,Fu-Xiang Zhou,Cong-Hua Xie,Chuang-Ying Xiao,Dong-Feng Pan,Zhi-Guo Luo,Shi-Quan Liu,Yun-Feng Zhou,Ya-Hua Zhong,Zheng-Kai Liao,Fu-Xiang Zhou,Cong-Hua Xie,Chuang-Ying Xiao,Dong-Feng Pan,Zhi-Guo Luo,Shi-Quan Liu,Yun-Feng Zhou,

A relationship between telomeres and radiosensitivity has been established by several studies based on non-mammalian model systems, mouse models, and few human genetic diseases. However, the relationship has not been proven in human carcinoma cells, which have more clinical significance than these other models. The present study aims to determine whether telomere length is related to radiosensitivity in human carcinoma cells, and to examine the influence of tissue or genetic background. Two HEp-2 larynx squamous carcinoma cell lines, eight hepatocellular carcinoma cell lines, and five breast cancer cell lines were used. Telomere length was determined by terminal restriction fragment (TRF) Southern blot analysis and cell survival was measured by a colony-forming assay. Our results indicated that there was a significant negative correlation of telomere length and radiosensitivity in the same tissue-derived cell lines, with or without the same genetic background. Thus, telomere length may be used as a promising tool to predict the radiosensitivity of human carcinomas.

Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. Publishing Authors By Initials

YH Zhong,ZK Liao,FX Zhou,CH Xie,CY Xiao,DF Pan,ZG Luo,SQ Liu,YF Zhou,YH Zhong,ZK Liao,FX Zhou,CH Xie,CY Xiao,DF Pan,ZG Luo,SQ Liu,YF Zhou,

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Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 367

Page Numbers: 84-9

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 26

MONTH: 12

YEAR: 2007

Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background.

AFFILIATION: Department of Chemo-Radiotherapy Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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