Telomere length and risk of Parkinson's disease.

Telomere length and risk of Parkinson's disease. Research Abstract Details 

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Telomere length and risk of Parkinson's disease. Abstract Text:

Hao Wang,Honglei Chen,Xiang Gao,Monica McGrath,Dwayne Deer,Immaculata De Vivo,Michael A Schwarzschild,Alberto Ascherio,

We investigated whether telomere length was associated with the risk of Parkinson's disease (PD) in a case-control study (96 cases and 172 age-matched controls) nested within the Health Professionals Follow-up Study. Relative ratio of telomere repeat copy number to single-gene copy number in peripheral blood leukocytes was determined by quantitative real time PCR. Men with shorter telomeres had a lower PD risk (multivariate adjusted relative risk for the lowest vs. the highest quartile 0.33; 95% confidence interval: 0.12-0.90). Our results suggest that, contrary to telomere attrition observed in several aging-related diseases, shorter telomeres are not associated with an increased risk of PD. (c) 2007 Movement Disorder Society.

Telomere length and risk of Parkinson's disease. Publishing Authors By Initials

H Wang,H Chen,X Gao,M McGrath,D Deer,I De Vivo,MA Schwarzschild,A Ascherio,

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Telomere length and risk of Parkinson's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Movement disorders : official journal of the Movem

VOLUME: 23

Page Numbers: 302-5

Journal Abbreviation: Mov. Disord.

ISSN: 0885-3185

DAY: 30

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts.

Country: United States

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MEDLINETA: Mov Disord

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