Telomere length and hTERT expression in patients with colorectal carcinoma.

Telomere length and hTERT expression in patients with colorectal carcinoma. Research Abstract Details 

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Telomere length and hTERT expression in patients with colorectal carcinoma. Abstract Text:

Robert Rosenberg,Ralf Gertler,Dominik Stricker,Silke Lassmann,Martin Werner,Hjalmar Nekarda,Joerg Ruediger Siewert,

The stabilization of telomere length by telomerase activation is an important step in carcinogenesis. Quantification of the catalytic telomerase subunit hTERT (human Telomerase Reverse Transcriptase) is a new indirect measure for telomerase. Telomere length and hTERT expression in cancer tissue and corresponding normal mucosa of 57 patients with completely resected colorectal carcinoma (UICC stage I-IV, R0) were determined for correlation with histopathological parameters and survival. Telomere lengths were measured using Southern Blot and hTERT-encoding mRNA was quantified by real-time RT-PCR. Telomere length and hTERT expression were significantly correlated in normal mucosa and cancer tissue (p<0.001). Telomere length and hTERT expression decreased with ageing only in normal mucosa. Cancer tissue had significantly shorter telomeres (p<0.001) and significantly lower hTERT expression levels (p<0.001) than corresponding normal mucosa. UICC stage I tumors showed significantly shorter telomeres than UICC stage II-IV tumors (p<0.002). Telomere length and hTERT expression were significantly correlated with overall survival. Telomere length and hTERT expression play an important role in ageing and carcinogenesis. Both parameters were identified as prognostic factors in patients with colorectal carcinoma.

Telomere length and hTERT expression in patients with colorectal carcinoma. Publishing Authors By Initials

R Rosenberg,R Gertler,D Stricker,S Lassmann,M Werner,H Nekarda,JR Siewert,

For similar chromosome structures: telomere research abstracts see: chromosome structures: telomere research

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Telomere length and hTERT expression in patients with colorectal carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 162

Page Numbers: 177-81

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 2003

Telomere length and hTERT expression in patients with colorectal carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 44671

Telomere length and hTERT expression in patients with colorectal carcinoma. Keywords Mesh Terms:

KEYWORDS: Telomere

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Telomere length and hTERT expression in patients with colorectal carcinoma. Information

Substance Name: Telomerase

Registry Number: EC 2.7.7.49

Grant and Affiliation Information for Telomere length and hTERT expression in patients with colorectal carcinoma.

AFFILIATION: Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.

Country: Germany

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MEDLINETA: Recent Results Cancer Res

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