Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.

Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. Research Abstract Details 

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Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. Abstract Text:

TLR22 occurs exclusively in aquatic animals and its role is unknown. Herein we show that the fugu (Takifugu rubripes) (fg)TLR3 and fgTLR22 link the IFN-inducing pathway via the fg Toll-IL-1R homology domain-containing adaptor protein 1(fgTICAM-1, or TRIF) adaptor in fish cells. fgTLR3 resides in endoplasmic reticulum and recognizes relatively short-sized dsRNA, whereas fgTLR22 recognizes long-sized dsRNA on the cell surface. On poly(I:C)-stimulated fish cells, both recruit fgTICAM-1, which in turn moves from the TLR to a cytoplasmic signalosome region. Thus, fgTICAM-1 acts as a shuttling platform for IFN signaling. When fish cells expressing fgTLR22 are exposed to dsRNA or aquatic dsRNA viruses, cells induce IFN responses to acquire resistance to virus infection. Thus, fish have a novel TICAM-1-coupling TLR that is distinct from the mammalian TLR3 in cellular localization, ligand selection, and tissue distribution. TLR22 may be a functional substitute of human cell-surface TLR3 and serve as a surveillant for infection with dsRNA virus to alert the immune system for antiviral protection in fish.

Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. Publishing Authors By Initials

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Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 181

Page Numbers: 3474-85

Journal Abbreviation: J. Immunol.

ISSN: 1550-6606

DAY: 1

MONTH: Sep

YEAR: 2008

Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.

AFFILIATION: Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan;

Country: United States

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MEDLINETA: J Immunol

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