Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits.

Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Research Abstract Details 

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Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Abstract Text:

Dae Chul Suh,Kil Soo Kim,Soo Mee Lim,Hai Bin Shi,Choong Gon Choi,Ho Kyu Lee,Dong Man Seo,

BACKGROUND AND PURPOSE: Liquid embolic agents may have potential as a therapeutic option to reconstruct a defective vessel wall. We evaluated the feasibility of transarterial glue embolization in surgically constructed carotid artery aneurysms. METHODS: Reconstruction of arterial wall defects with use of glue casts was performed in 16 surgically constructed aneurysms of carotid arteries in rabbits. Via the transfemoral route, glue was injected without balloon protection through a microcatheter into the aneurysmal sac with (n = 8) and without (n = 8) a framework of coils. To identify safe and effective methods, four concentrations (28%, 33%, 40%, 50%) of glue-iodized oil mixtures were used in four aneurysms each. Immediate (n = 16) and 2-month follow-up (n = 10) postembolization angiograms were obtained to evaluate the residual aneurysmal sac and the carotid artery patency. RESULTS: Continuous column injection of glue was possible in all aneurysms, without fragmented migration of the injected glue cast. Catheter sticking or breakage did not occur during catheter retrieval. Glue embolization without a framework of coils (n = 8) resulted in complete obliteration of the aneurysmal sac in five aneurysms and incomplete obliteration with a small residual lumen in three. Two aneurysms resulted in carotid occlusion after catheter removal. A follow-up angiogram (n = 4) showed decreased residual lumen in two aneurysms, no change in the complete aneurysm occlusion in one, and carotid occlusion in one. Glue embolization with a coil framework (n = 8) resulted in complete obliteration of the aneurysmal sac in six aneurysms and incomplete obliteration with a small residual lumen in two. A small amount of spillage occurred in one owing to the improper position of the microcatheter caused by a difficult neck angle to the parent artery. Follow-up angiograms (n = 6) showed decreased residual lumen in one of two aneurysms and no change of the complete occlusion in five of six aneurysms. CONCLUSION: Effective glue embolization into the aneurysmal sac is technically feasible. Microcatheter position within the aneurysm, concentration of glue, and direction of the aneurysmal neck angle all must be considered. With a coil framework, glue injection was more complete, without deformity or spillage of the glue from the aneurysm.

Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Publishing Authors By Initials

DC Suh,KS Kim,SM Lim,HB Shi,CG Choi,HK Lee,DM Seo,

For similar biomedical and dental materials: tissue adhesives research abstracts see: biomedical and dental materials: tissue adhesives research

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Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 24

Page Numbers: 1532-9

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ISSN: 0195-6108

DAY: 14

MONTH: Sep

YEAR: 2003

Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Keywords Mesh Terms:

KEYWORDS: Tissue Adhesives

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits. Information

Substance Name: Enbucrilate

Registry Number: 6606-65-1

Grant and Affiliation Information for Technical feasibility of embolizing aneurysms with glue (N-butyl 2-cyanoacrylate): experimental study in rabbits.

AFFILIATION: Department of Radiology, University of Ulsan, College of Medicine, Seoul, Korea.

Country: United States

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MEDLINETA: AJNR Am J Neuroradiol

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