Tcf3 governs stem cell features and represses cell fate determination in skin.

Tcf3 governs stem cell features and represses cell fate determination in skin. Research Abstract Details 

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Tcf3 governs stem cell features and represses cell fate determination in skin. Abstract Text:

Hoang Nguyen,Michael Rendl,Elaine Fuchs,

Many stem cells (SCs) respond to Wnt signaling, but whether beta-catenin's DNA binding partners, the Tcfs, play a role in SCs in the absence of Wnts, is unknown. In adult skin, quiescent multipotent progenitors express Tcf3 and commit to a hair cell fate in response to Wnt signaling. We find that embryonic skin progenitors also express Tcf3. Using an inducible system in mice, we show that upon Tcf3 reactivation, committed epidermal cells induce genes associated with an undifferentiated, Wnt-inhibited state and Tcf3 promotes a transcriptional program shared by embryonic and postnatal SCs. Further, Tcf3-repressed genes include transcriptional regulators of the epidermal, sebaceous gland and hair follicle differentiation programs, and correspondingly, all three terminal differentiation pathways are suppressed when Tcf3 is induced postnatally. These data suggest that in the absence of Wnt signals, Tcf3 may function in skin SCs to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage.

Tcf3 governs stem cell features and represses cell fate determination in skin. Publishing Authors By Initials

H Nguyen,M Rendl,E Fuchs,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

PUBMED ID PMID:

MEDLINE DATE:

Tcf3 governs stem cell features and represses cell fate determination in skin. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell

VOLUME: 127

Page Numbers: 171-83

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 6

MONTH: Oct

YEAR: 2006

Tcf3 governs stem cell features and represses cell fate determination in skin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413066

Tcf3 governs stem cell features and represses cell fate determination in skin. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Tcf3 governs stem cell features and represses cell fate determination in skin. Information

Substance Name: Doxycycline

Registry Number: 564-25-0

Grant and Affiliation Information for Tcf3 governs stem cell features and represses cell fate determination in skin.

AFFILIATION: Howard Hughes Medical Institute, Department of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, Box 300, New York, NY 10021, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR31737

ACRONYM: AR

MEDLINETA: Cell

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