Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.

Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Research Abstract Details 

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Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Abstract Text:

Frederick J Bonte,Thomas S Harris,Linda S Hynan,Eileen H Bigio,Charles L White,

PURPOSE: The purpose of this study is to determine the value of Tc-99m HMPAO SPECT in the diagnosis of the dementias, with particular reference to Alzheimer disease. MATERIALS AND METHODS: Tc-99m HMPAO was used with a 3-camera scanner to produce 5 sets of sectional images of the brain. Diagnosis was made by a physician blinded to the clinical diagnosis. Results in 49 subjects were ultimately compared with neuropathologic study of the brain at autopsy. RESULTS: Sensitivity = 86.7% (68.4-95.6%, 95% confidence interval [CI]), specificity = 89.5% (65.5-98.2% CI), positive predictive value = 92.9% (75.0-98.8% CI), negative predictive value = 81% (57.4-93.7% CI), accuracy = 87.8% (74.5-94.9% CI), likelihood ratio = 8.23% (7.09-9.57% CI). CONCLUSIONS: Comparison is made with several other SPECT and PET series with histopathologic correlation. Brain blood flow SPECT is useful in the diagnosis and differential diagnosis of the dementias.

Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Publishing Authors By Initials

FJ Bonte,TS Harris,LS Hynan,EH Bigio,CL White,

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Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Clinical nuclear medicine

VOLUME: 31

Page Numbers: 376-8

Journal Abbreviation:

ISSN: 0363-9762

DAY: 3

MONTH: Jul

YEAR: 2006

Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7611109

Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed, Single-Ph

MESH TERMS: methods

Chemical & Substance for Abstract: Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Information

Substance Name: Technetium Tc 99m Exametazime

Registry Number: 100504-35-6

Grant and Affiliation Information for Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation.

AFFILIATION: Nuclear Medicine Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9061, USA. Frederick.Bonte@UTSouthwestern.edu

Country: United States

AGENCY: United States NIA

GRANT: AG 12300

ACRONYM: AG

MEDLINETA: Clin Nucl Med

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