Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species.

Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Research Abstract Details 

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Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Abstract Text:

P Shen,B L Guo,Y Gong,Deborah Y Q Hong,Y Hong,E L Yong,

To understand the factors contributing to estrogenic properties of extracts from the genus Epimedium L. (Berberidaceae), we performed taxonomic, genetic and chemical characterization on 37 specimens from 18 species and related these to estrogen receptor (ERalpha and ERbeta) bioactivity, as measured by reporter genes in stable human cells. Boot strap values derived from amplified fragment length polymorphisms indicated that specimens of E. koreanum, E. brevicornum, E. myrianthum, E. leishanense, and E. membranaceum were genetically distinct and this was supported by their very similar ERalpha activities. In contrast, specimens from E. pubescens and E. sagittatum were diverse both genetically, chemically and in terms of ERalpha and ERbeta bioactivities. Strikingly, a genetic cluster comprising six rare Epimedium species exhibited strongest ERalpha and ERbeta activity, and this bioactivity was positively correlated with content of trace flavonoid aglycones (kaempferol, apigenin, quercetin, luteolin and breviflavone B). In contrast, there was no association between estrogenic activity and the major flavonol glycoside constituents (icariin and epimedin A-C). Although they exhibited equally strong ERalpha and ERbeta activity, E. koreanum can be clearly differentiated from E. pubescens and E. brevicornum by genetic distance and its significantly lower content of epimedin C. Our morphologic, genetic, chemical and bioactivity profiling provide the basis for the production of extracts with reproducible estrogenic properties. Such reproducibility will be critical for the standardization of Epimedium-based products.

Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Publishing Authors By Initials

P Shen,BL Guo,Y Gong,DY Hong,Y Hong,EL Yong,

For similar genetic phenomena: variation (genetics): polymorphism, genetic research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic research

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Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Phytochemistry

VOLUME: 68

Page Numbers: 1448-58

Journal Abbreviation:

ISSN: 0031-9422

DAY: 16

MONTH: 04

YEAR: 2007

Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 151434

Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Information

Substance Name: Phytoestrogens

Registry Number: 0

Grant and Affiliation Information for Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species.

AFFILIATION: Department of Obstetrics and Gynecology, National University Hospital, Yong Loo Lin School of Medicine, Lower Kent Ridge Road, Singapore 119074, Republic of Singapore.

Country: United States

AGENCY: United States NCCAM

GRANT: 1 R21 AT001945-01

ACRONYM: AT

MEDLINETA: Phytochemistry

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