Taurine transporter is expressed in vascular smooth muscle cells.

Taurine transporter is expressed in vascular smooth muscle cells. Research Abstract Details 

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Taurine transporter is expressed in vascular smooth muscle cells. Abstract Text:

X-B Liao,X-M Zhou,J-M Li,Z-P Tan,L-M Liu,W Zhang,H Tan,Y Lu,L-Q Yuan,X-B Liao,X-M Zhou,J-M Li,Z-P Tan,L-M Liu,W Zhang,H Tan,Y Lu,L-Q Yuan,X-B Liao,X-M Zhou,J-M Li,Z-P Tan,L-M Liu,W Zhang,H Tan,Y Lu,L-Q Yuan,

The regulation of vascular smooth muscle cells (VSMCs) function by taurine has been a subject of increasing interest and investigation, and taurine is taken up into cells through a specific transporter system, the taurine transporter (TAUT). In the present study, we examined the expression of TAUT in VSMCs and the kinetic parameters of the uptake process of TAUT in VSMCs. RT-PCR and western blot demonstrated that the mRNA and protein of TAUT was expressed in VSMCs in vitro. Immunohistochemistry using antibody for TAUT revealed the expression of this protein in rat thoracic aorta. The maximal [(3)H]taurine uptake rate in VSMCs was 37.75 +/- 3.13 pmol/min per mg of protein, with a K ( m ) value of 5.42 +/- 0.81 microM. Thus, VSMCs are able to express a functional taurine transporter. The regulation and detailed function of taurine and TAUT in VSMCs remain unclear, but our findings suggest a functional role for them in VSMCs metabolism.

Taurine transporter is expressed in vascular smooth muscle cells. Publishing Authors By Initials

XB Liao,XM Zhou,JM Li,ZP Tan,LM Liu,W Zhang,H Tan,Y Lu,LQ Yuan,XB Liao,XM Zhou,JM Li,ZP Tan,LM Liu,W Zhang,H Tan,Y Lu,LQ Yuan,XB Liao,XM Zhou,JM Li,ZP Tan,LM Liu,W Zhang,H Tan,Y Lu,LQ Yuan,

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Taurine transporter is expressed in vascular smooth muscle cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Amino acids

VOLUME: 33

Page Numbers: 639-43

Journal Abbreviation: Amino Acids

ISSN: 0939-4451

DAY: 26

MONTH: 01

YEAR: 2007

Taurine transporter is expressed in vascular smooth muscle cells. Information

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LANGUAGE: eng

NlmUniqueID: 9200312

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Grant and Affiliation Information for Taurine transporter is expressed in vascular smooth muscle cells.

AFFILIATION: Department of Cardiothoracic Surgery, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.

Country: Austria

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MEDLINETA: Amino Acids

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