Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Abstract Text:

It is currently accepted that tau overexpression leads to impaired organelle transport and thus to neuronal degeneration. Nevertheless, the underlying mechanisms that lead to impaired organelle transport are not entirely clear. Using cultured Aplysia neurons and online confocal imaging of human tau, microtubules (MTs), the plus-end tracking protein - end-binding protein 3, retrogradely and anterogradely transported organelles, we found that overexpression of tau generates the hallmarks of human tau pathogenesis. Nevertheless, in contrast to earlier reports, we found that the tau-induced impairment of organelle transport is because of polar reorientation of the MTs along the axon or their displacement to submembrane domains. 'Traffic jams' reflect the accumulation of organelles at points of MT polar discontinuations or polar mismatching rather than because of MT depolymerization. Our findings offer a new mechanistic explanation for earlier observations, which established that tau overexpression leads to impaired retrograde and anterograde organelle transport, while the MT skeleton appeared intact.

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Traffic (Copenhagen, Denmark)

VOLUME: 9

Page Numbers: 458-71

Journal Abbreviation: Traffic

ISSN: 1398-9219

DAY: 21

MONTH: 12

YEAR: 2007

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100939340

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.

AFFILIATION: Department of Neurobiology, Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Traffic

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching Related Publications

• A new rapid and effective method for treatment of unexplained infertility.
• Blood loss and replacement in plasmodial infections. V. Positive antiglobulin tests in rat anemias due to the rodent malarias Plasmodium berghei and Plasmodium vinckei, to cardiac bleeding, and to treatment with phenylhydrazine hydrochloride.
• Bridging of bone defects in the forearm with iliac graft combined with intramedullary nailing.
• CT diagnosis of benign mediastinal abnormalities.
• Calcium-induced exocytosis from actomyosin-driven, motile varicosities formed by dynamic clusters of organelles.
• Chest CT for detection of pneumothorax after lung biopsy.
• Comparison of smoking-induced gene expression on affymetrix exon and 3'-based expression arrays.
• Discussion: the history of injectable silicone fluids for soft-tissue augmentation.
• Diving and marine medicine review part I: diving physics and physiology.
• Diving and marine medicine review part II: diving diseases.
• Experimental fluorosis in rats.
• Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats.
• Helicobacter pylori and progressive gastric pathology that predisposes to gastric cancer.
• Immune response to gamma-irradiated injectable human amnion and human skin collagens in the rat.
• Local self-assembly mechanisms underlie the differential transformation of the proximal and distal cut axonal ends into functional and aberrant growth cones.
• Local self-assembly mechanisms underlie the differential transformation of the proximal and distal cut axonal ends into functional and aberrant growth cones.
• Local self-assembly mechanisms underlie the differential transformation of the proximal and distal cut axonal ends into functional and aberrant growth cones.
• More on informed consent.
• Replacement of biceps brachii by pectoralis minor transplant.
• Reproductive life events in the population living in the vicinity of a nuclear waste reprocessing plant.
• Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression.
• Reversible transition of extracellular field potential recordings to intracellular recordings of action potentials generated by neurons grown on transistors.
• Sensitivity analysis in summary measure of population health in France.
• Setting the standard.
• Stigmata of degeneration in fluorosis.
• Subtotal ear reconstruction for correction of type 3 constricted ear.
• Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.
• Variation in stress responses within a bacterial species and the indirect costs of stress resistance.
• Yellow fever vaccine as a vehicle to better travel medicine.
• [EPH 2007 and after.]