Targeting the PI3K-Akt pathway in kidney cancer.

Targeting the PI3K-Akt pathway in kidney cancer. Research Abstract Details 

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Targeting the PI3K-Akt pathway in kidney cancer. Abstract Text:

Jin-Young Park,Pei-yin Lin,Robert H Weiss,Jin-Young Park,Pei-yin Lin,Robert H Weiss,

Kidney cancer, or renal cell carcinoma, is a relatively rare malignancy but is metastatic at diagnosis in a third of patients; metastatic disease has a dismal prognosis. Conventional chemotherapy has been woefully inadequate, thus novel targets for 'designer' therapies are being actively evaluated. The PI3K-Akt signaling cascade, owing to its dual role in both survival and mitogenic signaling, is in theory an ideal therapeutic target for this disease, but may also represent its fatal flaw. Thus, largely due to toxicity issues, no PI3K or Akt inhibitors are currently ready for clinical application. In this review, we discuss PI3K-Akt inhibitors as well as inhibitors of pathways and targets both immediately up- and downstream of this cascade, many of which show promise in the clinic.

Targeting the PI3K-Akt pathway in kidney cancer. Publishing Authors By Initials

JY Park,PY Lin,RH Weiss,JY Park,PY Lin,RH Weiss,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Targeting the PI3K-Akt pathway in kidney cancer. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of anticancer therapy

VOLUME: 7

Page Numbers: 863-70

Journal Abbreviation: Expert Rev Anticancer Ther

ISSN: 1744-8328

DAY: 3

MONTH: Jun

YEAR: 2007

Targeting the PI3K-Akt pathway in kidney cancer. Information

Number of References: 101

LANGUAGE: eng

NlmUniqueID: 101123358

Targeting the PI3K-Akt pathway in kidney cancer. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Targeting the PI3K-Akt pathway in kidney cancer. Information

Substance Name: Proto-Oncogene Proteins c-akt

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Targeting the PI3K-Akt pathway in kidney cancer.

AFFILIATION: Division of Nephrology, Department of Internal Medicine, Immunology Graduate Group, University of California, Davis, CA 95616, USA. jyppark@ucdavis.edu

Country: England

AGENCY: United States NCI

GRANT: 1R21CA 91259–01A1

ACRONYM: CA

MEDLINETA: Expert Rev Anticancer Ther

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