Targeting telomerase for cancer therapeutics.

Targeting telomerase for cancer therapeutics. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Targeting telomerase for cancer therapeutics. Abstract Text:

J W Shay,W N Keith,J W Shay,W N Keith,

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.British Journal of Cancer (2008) 98, 677-683. doi:10.1038/sj.bjc.6604209 www.bjcancer.com Published online 29 January 2008.

Targeting telomerase for cancer therapeutics. Publishing Authors By Initials

JW Shay,WN Keith,JW Shay,WN Keith,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Targeting telomerase for cancer therapeutics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of cancer

VOLUME: 98

Page Numbers: 677-83

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 29

MONTH: 01

YEAR: 2008

Targeting telomerase for cancer therapeutics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370635

Targeting telomerase for cancer therapeutics. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Targeting telomerase for cancer therapeutics. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Targeting telomerase for cancer therapeutics.

AFFILIATION: 1Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9030, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Br J Cancer

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Targeting telomerase for cancer therapeutics Related Publications

• A comparison of general and age-specific factors associated with political behavior.
• Angiocardiography in infants and children.
• Complications of temporomandibular joint surgery.
• Decreased waiting periods in a public pregnancy termination clinic.
• Electrode fracture rates and occurrences of infection and granuloma associated with percutaneous intramuscular electrodes in upper-limb functional electrical stimulation applications.
• Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.
• Feedback to doctors about prescribing errors in the hospital setting.
• Headache, irritability and fatigue.
• INTRAVENOUS UREA IN GLAUCOMA.
• Interleukin-11.
• Introduction and Overview: 481: 9:00 AM-9:10 AM.
• Joint ventures and home health care.
• Linking leaf and tree water use with an individual-tree model.
• Mercury transport and bioaccumulation in riverbank communities of the Alvarado Lagoon System, Veracruz State, Mexico.
• Nursing home administrators' views of their own and volunteer resident advocates' enhancement of long-term care.
• One step conversion of heteroaromatic-N-oxides to imidazolo-heteroarenes.
• Physicians' opinions of expanded clinical pharmacy services.
• Preliminary open trial of interpersonal counseling for subsyndromal depression following miscarriage.
• Prolonged penicillemia following the intramuscular injection of benzethacil in children.
• Putting laparoscopy on the academic map: early and continuing scholarship by the AAGL.
• Sir Arthur Keith centenary.
• Some observations on diminished responsibility.
• Stem cell ageing: does it happen and can we intervene?
• Subdural empyema.
• Targeting telomerase for cancer therapeutics.
• Telomerase redefined: Integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity.
• The influence of pteroylglutamic acid on glycine and on porphyrin metabolism.
• The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
• The work-satisfaction, retirement-attitude typology: profile examination.
• [Sterilization using the laparoscope]