Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles.

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Research Abstract Details 

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Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Abstract Text:

Masaki Uchida,Michelle L Flenniken,Mark Allen,Deborah A Willits,Bridgid E Crowley,Susan Brumfield,Ann F Willis,Larissa Jackiw,Mark Jutila,Mark J Young,Trevor Douglas,

Protein cage architectures such as virus capsids and ferritins are versatile nanoscale platforms amenable to both genetic and chemical modification. Incorporation of multiple functionalities within these nanometer-sized protein architectures demonstrate their potential to serve as functional nanomaterials with applications in medical imaging and therapy. In the present study, we synthesized an iron oxide (magnetite) nanoparticle within the interior cavity of a genetically engineered human H-chain ferritin (HFn). A cell-specific targeting peptide, RGD-4C which binds alphavbeta3 integrins upregulated on tumor vasculature, was genetically incorporated on the exterior surface of HFn. Both magnetite-containing and fluorescently labeled RGD4C-Fn cages bound C32 melanoma cells in vitro. Together these results demonstrate the capability of a genetically modified protein cage architecture to serve as a multifunctional nanoscale container for simultaneous iron oxide loading and cell-specific targeting.

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Publishing Authors By Initials

M Uchida,ML Flenniken,M Allen,DA Willits,BE Crowley,S Brumfield,AF Willis,L Jackiw,M Jutila,MJ Young,T Douglas,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 16626-33

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 27

MONTH: Dec

YEAR: 2006

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: drug effects

Chemical & Substance for Abstract: Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. Information

Substance Name: Ferritins

Registry Number: 9007-73-2

Grant and Affiliation Information for Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles.

AFFILIATION: Department of Chemistry and Biochemistry, and Center for Bio-Inspired Nanomaterials (CBIN), Montana State University, Bozeman, MT 59717, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: R21 EB 005364

ACRONYM: EB

MEDLINETA: J Am Chem Soc

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