Targeting host cells harbouring viruses with radiolabeled antibodies.

Targeting host cells harbouring viruses with radiolabeled antibodies. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Targeting host cells harbouring viruses with radiolabeled antibodies. Abstract Text:

Arturo Casadevall,Harris Goldstein,Ekaterina Dadachova,

Existing antiviral therapies produce a therapeutic effect by suppressing viral replication and reducing viral burden and the associated inflammatory reaction. However, infection with many viruses results in chronic infections that cannot be eradicated by the immune response or available antiviral drugs. As viruses are obligate intracellular pathogens, it should be possible to eradicate chronic infections by targeting and eliminating the infected host cells. Radioisotope-conjugated antibodies that specifically bind viral antigens can deliver cytotoxic radiation to virally infected cells. This approach was recently shown to target and eliminate HIV-1-infected cells in vitro and in mouse models, and provides a new approach for eliminating virally infected cells.

Targeting host cells harbouring viruses with radiolabeled antibodies. Publishing Authors By Initials

A Casadevall,H Goldstein,E Dadachova,

For similar virus diseases research abstracts see: virus diseases research

PUBMED ID PMID:

MEDLINE DATE:

Targeting host cells harbouring viruses with radiolabeled antibodies. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Expert opinion on biological therapy

VOLUME: 7

Page Numbers: 595-7

Journal Abbreviation:

ISSN: 1744-7682

DAY: 3

MONTH: May

YEAR: 2007

Targeting host cells harbouring viruses with radiolabeled antibodies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101125414

Targeting host cells harbouring viruses with radiolabeled antibodies. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: virology

Chemical & Substance for Abstract: Targeting host cells harbouring viruses with radiolabeled antibodies. Information

Substance Name: Radioisotopes

Registry Number: 0

Grant and Affiliation Information for Targeting host cells harbouring viruses with radiolabeled antibodies.

AFFILIATION: Albert Einstein College of Medicine, Department of Microbiology and Immunology, 1300 Morris Park Ave, Bronx, NY 10461, USA. casadeva@aecom.yu.edu

Country: England

AGENCY: United States NIAID

GRANT: U54-AI057158

ACRONYM: AI

MEDLINETA: Expert Opin Biol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Targeting host cells harbouring viruses with radiolabeled antibodies Related Publications

• Chemosorption of radiometals of interest to nuclear medicine by synthetic melanins.
• Computational model predicts effective delivery of 188-Re-labeled melanin-binding antibody to metastatic melanoma tumors with wide range of melanin concentrations.
• Finite-Element Model of Interaction between Fungal Polysaccharide and Monoclonal Antibody in the Capsule of Cryptococcus neoformans.
• Phage Display Library Derived Peptides that Bind to Human Tumor Melanin as Potential Vehicles for Targeted Radionuclide Therapy of Metastatic Melanoma.
• Radiofungicidal Effects of External Gamma Radiation and Antibody-Targeted Beta and Alpha Radiation on Cryptococcus neoformans.
• Targeting host cells harbouring viruses with radiolabeled antibodies.
• Treating cancer as an infectious disease-viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology.