Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate.

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Abstract Text:

Dubuc, Langlois, ,Nicole Cauchon,Klaus Klarskov,Paul Tone,Johan E van Lier, Dubuc, Langlois, ,Nicole Cauchon,Klaus Klarskov,Paul Tone,Johan E van Lier,

Sulfonated aluminum phthalocyanines (AlPcS) are potent photosensitizers for the photodynamic therapy (PDT) of cancer. In this study we evaluate the possibility to improve the efficacy of AlPcS-PDT for prostate cancer by targeting tetrasulfonated aluminum phthalocyanines (AlPcS(4)) to the gastrin-releasing peptide receptor (GRPR) through coupling to bombesin. A mono-carbohexyl derivative of AlPcS(4) is attached to 8-Aoc-bombesin(7-14)NH(2) via an amide bridge to yield a bombesin-AlPcS(4) conjugate linked by a C-14 spacer chain. The conjugate is characterized by mass spectroscopy and shown to bind to the GRPR with a relative binding affinity (RBA) of 2.3, taking bombesin (RBA=100) as unity. The in vitro photodynamic efficacy of the conjugate against PC-3 human prostate cancer cells is improved by a factor 2.5 over the non-conjugated mono-carbohexyl derivative of AlPcS(4).

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Publishing Authors By Initials

C Dubuc,R Langlois,F ,N Cauchon,K Klarskov,P Tone,JE van Lier,C Dubuc,R Langlois,F ,N Cauchon,K Klarskov,P Tone,JE van Lier,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 2424-7

Journal Abbreviation:

ISSN: 1464-3405

DAY: 26

MONTH: 02

YEAR: 2008

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate.

AFFILIATION: Department of Nuclear Medicine & Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, Que., Canada J1H 5N4.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate Related Publications

• A fingerprint left by cytomegalovirus infection in the human T cell compartment.
• Adapting UASB technology for sewage treatment in Palestine and Jordan.
• Adequate synapse formation between leukemic B cells and effector T cells following stimulation with artificial TCR ligands.
• Biodistribution and tumor uptake of [67Ga]chlorogallium-tetraoctadecyloxy phthalocyanine and its sulfonation products in tumor bearing C3H mice.
• CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets.
• CD27: marker and mediator of T-cell activation?
• CD70 represents the human ligand for CD27.
• Characterization of murine CD70, the ligand of the TNF receptor family member CD27.
• Characterization of the human CD27 ligand, a novel member of the TNF gene family.
• Cytotoxic human CD4(+) T cells.
• Differential Regulation of Human IL-7 Receptor {alpha} Expression by IL-7 and TCR Signaling.
• Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation.
• Expression of the murine CD27 ligand CD70 in vitro and in vivo.
• Grouping effects in flash-induced perceptual fading.
• Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells.
• Infarcted heart uptake and biodistribution of radiolabelled anti-myosin monoclonal antibody in rat and dog myocardial infarct models.
• Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions.
• Oxidation and reactivity of nitrogen- and phosphorus-doped heterofullerenes.
• Photodynamic inhibition of acetylcholinesterase after two-photon excitation of copper tetrasulfophthalocyanine.
• Sterol metabolism. IV. Microbial disposition of 5beta-cholestan-3beta-ol.
• Synthesis, receptor binding and target-tissue uptake of carbon-11-labeled carbamate derivatives of estradiol and hexestrol.
• Targeting gastrin-releasing peptide receptors of prostate cancer cells for photodynamic therapy with a phthalocyanine-bombesin conjugate.
• The size and phenotype of virus-specific T cell populations is determined by repetitive antigenic stimulation and environmental cytokines.
• Thermophilic treatment of acidified and partially acidified wastewater using an anaerobic submerged MBR: Factors affecting long-term operational flux.
• [(18)F]Fluorinated estradiol derivatives for oestrogen receptor imaging: impact of substituents, formulation and specific activity on the biodistribution in breast tumour-bearing mice.