Targeting G protein-coupled receptor signaling in asthma.

Targeting G protein-coupled receptor signaling in asthma. Research Abstract Details 

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Targeting G protein-coupled receptor signaling in asthma. Abstract Text:

Deepak A Deshpande,Raymond B Penn,

The complex disease asthma, an obstructive lung disease in which excessive airway smooth muscle (ASM) contraction as well as increased ASM mass reduces airway lumen size and limits airflow, can be viewed as a consequence of aberrant airway G protein-coupled receptor (GPCR) function. The central role of GPCRs in determining airway resistance is underscored by the fact that almost every drug used in the treatment of asthma directly or indirectly targets either GPCR-ligand interaction, GPCR signaling, or processes that produce GPCR agonists. Although many airway cells contribute to the regulation of airway resistance and architecture, ASM properties and functions have the greatest impact on airway homeostasis. The theme of this review is that GPCR-mediated regulation of ASM tone and ASM growth is a major determinant of the acute and chronic features of asthma, and multiple strategies targeting GPCR signaling may be employed to prevent or manage these features.

Targeting G protein-coupled receptor signaling in asthma. Publishing Authors By Initials

DA Deshpande,RB Penn,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Targeting G protein-coupled receptor signaling in asthma. Journal Published:

PUBLICATION TYPE: Review

Journal: Cellular signalling

VOLUME: 18

Page Numbers: 2105-20

Journal Abbreviation: Cell. Signal.

ISSN: 0898-6568

DAY: 7

MONTH: 07

YEAR: 2006

Targeting G protein-coupled receptor signaling in asthma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904683

Targeting G protein-coupled receptor signaling in asthma. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Targeting G protein-coupled receptor signaling in asthma. Information

Substance Name: Receptors, G-Protein-Coupled

Registry Number: 0

Grant and Affiliation Information for Targeting G protein-coupled receptor signaling in asthma.

AFFILIATION: Department of Internal Medicine and Center for Human Genomics, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157, United States.

Country: England

AGENCY: United States NHLBI

GRANT: HL58506

ACRONYM: HL

MEDLINETA: Cell Signal

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