Targeting APL fusion proteins by peptide interference.

Targeting APL fusion proteins by peptide interference. Research Abstract Details 

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Targeting APL fusion proteins by peptide interference. Abstract Text:

A Melnick,

A significant barrier to experimental therapeutics is the ability to identify and specifically target oncogenic proteins involved in the molecular pathogenesis of disease. In acute promyelocytic leukemia (APL), aberrant transcription factors and their associated machinery play a central role in mediating the malignant phenotype. The mechanism of action of APL chimeric fusion proteins involves their ability to either self-associate or interact with different partner proteins. Thus, targeting protein-protein interactions could have a significant impact in blocking the activity of APL oncoproteins. As therapeutic targets, the interface between interacting proteins may not always be amenable to highly specific small molecule blockade. In contrast, peptides are well-suited to this purpose and can be reliably delivered when fused to cell-permeable peptide domains. Therapeutic peptides can be designed to directly target APL fusion proteins, their downstream effectors, or other potentially synergistic oncogenic mechanisms of importance in APL blasts. In addition to serving as potential therapeutic agents, such reagents could serve as powerful reagents to dissect the molecular pathogenesis of APL.

Targeting APL fusion proteins by peptide interference. Publishing Authors By Initials

A Melnick,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Targeting APL fusion proteins by peptide interference. Journal Published:

PUBLICATION TYPE: Review

Journal: Current topics in microbiology and immunology

VOLUME: 313

Page Numbers: 221-43

Journal Abbreviation: Curr. Top. Microbiol. Immunol.

ISSN: 0070-217X

DAY: 3

MONTH: 12

YEAR: 2007

Targeting APL fusion proteins by peptide interference. Information

Number of References: 90

LANGUAGE: eng

NlmUniqueID: 110513

Targeting APL fusion proteins by peptide interference. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Targeting APL fusion proteins by peptide interference. Information

Substance Name: promyelocytic leukemia-retinoic acid rec

Registry Number: 0

Grant and Affiliation Information for Targeting APL fusion proteins by peptide interference.

AFFILIATION: Department of Developmental and Molecular Biology and Medical Oncology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA. amelnick@aecom.yu.edu

Country: Germany

AGENCY: United States NCI

GRANT: R01 CA104348

ACRONYM: CA

MEDLINETA: Curr Top Microbiol Immunol

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