Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning.

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Abstract Text:

Alexander W Johnson,David Bannerman,Nick Rawlins,Rolf Sprengel,Mark A Good,Alexander W Johnson,David Bannerman,Nick Rawlins,Rolf Sprengel,Mark A Good,

The authors assessed the hypothesis that deletion of the GluR-1 subtype of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor in mice disrupts the associative activation of a sensory-specific representation of an appetitive reward. In Experiment 1, mice received training on a Pavlovian-instrumental transfer task. In the test stage, conditioned stimulus (CS) presentations enhanced instrumental actions in both groups. However, this effect was specific to the action that shared the same outcome as the CS in wild-type (WT), but not GluR-1-super(-/-), mice. In Experiment 2, the mice were trained on a heterogeneous instrumental chain in which rewards were obtained for emitting 1 response (R1, that was distal to reward delivery), followed by a 2nd response (R2, that was proximal to reward delivery). A change in general motivational state (from hungry to sated) reduced the number of R2 responses in both groups. In contrast, an outcome-specific satiety treatment produced a selective decline in R1 responding only in WT mice. The results support the hypothesis that GluR-1 deletion impairs the associative activation of a representation of the sensory-specific incentive motivational properties of an appetitive reward. (PsycINFO Database Record (c) 2007 APA, all rights reserved).

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Publishing Authors By Initials

AW Johnson,D Bannerman,N Rawlins,R Sprengel,MA Good,AW Johnson,D Bannerman,N Rawlins,R Sprengel,MA Good,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Behavioral neuroscience

VOLUME: 121

Page Numbers: 1192-202

Journal Abbreviation: Behav. Neurosci.

ISSN: 0735-7044

DAY: 18

MONTH: Dec

YEAR: 2007

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8302411

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning.

AFFILIATION: School of Psychology, Cardiff University.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Behav Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning Related Publications

• A case for whole-parasite malaria vaccines.
• A rapid method to measure beta-amyloid induced neurotoxicity in vitro.
• A small epidemic with meningeal symptoms simulating leptospiral infection.
• Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease.
• Antigen-antibody mechanisms in neurotropic virus diseases.
• Attenuation of beta-amyloid induced toxicity by sialic acid-conjugated dendrimeric polymers.
• Attenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment.
• Culture and stigma: adding moral experience to stigma theory.
• Determinants of complementary and alternative medicine use by patients with bipolar disorder.
• Diagnosis and treatment of low backache.
• Effects of celecoxib on blood loss, pain, and recovery of function after total knee replacement: a randomized placebo-controlled trial.
• Energy balance pathways converging on the Nhlh2 transcription factor.
• Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability.
• Group clinic starts a new chapter in the history of rural medical care.
• Immunodeficiency, radiosensitivity, and the XCIND syndrome.
• Intranasal administration is an effective mucosal vaccine delivery route for self-adjuvanting lipid core peptides targeting the group A streptococcal M protein.
• Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group A streptococcus challenge and reduces throat colonization.
• Introduction: Robert A. Good Immunology Conference 2007.
• Lack of identity of hyaluronidase inhibitor and certain mucoproteins in blood serum.
• Nongenomic actions of aldosterone on the renal tubule.
• Novel DOCK clique driven 3D similarity database search tools for molecule shape matching and beyond: adding flexibility to the search for ligand kin.
• Reliability and Validity of the Sensewear Pro Armband During Continuous Functional Resistance Exercise: 1301: Board #64 May 30 9:30 AM - 11:00 AM.
• Response 2.
• Robert A Good and Ludwig van Beethoven: immortal beloveds: summary of the Robert A Good Immunology Society: Perspective in Immunology 2006 June 9-12 2006 St. Pete Beach, Florida.
• Robert A. Good, the March of Dimes, and immunodeficiency: an historical perspective.
• Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway.
• Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning.
• Technology and retinopathy of prematurity diagnosis: the new frontier.
• The importance of exploratory thoracotomy in the diagnosis of certain pulmonary lesions.
• The spectrum of vision impairment caused by pediatric neurological injury.