Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Research Abstract Details 

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Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Abstract Text:

Sawako Tatsumi,Kiyoaki Ishii,Norio Amizuka,Minqi Li,Toshihiro Kobayashi,Kenji Kohno,Masako Ito,Sunao Takeshita,Kyoji Ikeda,

Bone remodeling is performed by osteoclasts and osteoblasts at the bone surface. Inside of bone is a network of numerous osteocytes, whose specific function has remained an enigma. Here we describe a transgenic mouse model in which inducible and specific ablation of osteocytes is achieved in vivo through targeted expression of diphtheria toxin (DT) receptor. Following a single injection of DT, approximately 70%-80% of the osteocytes, but apparently no osteoblasts, were killed. Osteocyte-ablated mice exhibited fragile bone with intracortical porosity and microfractures, osteoblastic dysfunction, and trabecular bone loss with microstructural deterioration and adipose tissue proliferation in the marrow space, all of which are hallmarks of the aging skeleton. Strikingly, these "osteocyte-less" mice were resistant to unloading-induced bone loss, providing evidence for the role of osteocytes in mechanotransduction. Thus, osteocytes represent an attractive target for the development of diagnostics and therapeutics for bone diseases, such as osteoporosis.

Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Publishing Authors By Initials

S Tatsumi,K Ishii,N Amizuka,M Li,T Kobayashi,K Kohno,M Ito,S Takeshita,K Ikeda,

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Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell metabolism

VOLUME: 5

Page Numbers: 464-75

Journal Abbreviation: Cell Metab.

ISSN: 1550-4131

DAY: 6

MONTH: Jun

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Bone and Joint Disease, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8522, Japan; National Institute of Biomedical Innovation, Osaka 567-0085, Japan.

Country: United States

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MEDLINETA: Cell Metab

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